نتایج جستجو برای: protein isoforms

تعداد نتایج: 1242693  

Journal: :Journal of Pharmacology and Experimental Therapeutics 2009

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Xiaowen Yang Wen Hwa Lee Frank Sobott Evangelos Papagrigoriou Carol V Robinson J Günter Grossmann Michael Sundström Declan A Doyle Jonathan M Elkins

The seven members of the human 14-3-3 protein family regulate a diverse range of cell signaling pathways by formation of protein-protein complexes with signaling proteins that contain phosphorylated Ser/Thr residues within specific sequence motifs. Previously, crystal structures of three 14-3-3 isoforms (zeta, sigma, and tau) have been reported, with structural data for two isoforms deposited i...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Christopher D Shaffer Gena E Stephens Brandi A Thompson Levi Funches John A Bernat Carolyn A Craig Sarah C R Elgin

Heterochromatin protein 1 (HP1), first discovered in Drosophila melanogaster, is a highly conserved chromosomal protein implicated in both heterochromatin formation and gene silencing. We report here characterization of an HP1-interacting protein, heterochromatin protein 2 (HP2), which codistributes with HP1 in the pericentric heterochromatin. HP2 is a large protein with two major isoforms of a...

AH Ahmadi E Rahimi F Khani Habib abadi, M Behmanesh

Background Environmental and cellular inappropriate conditions can cause damages to cells nucleotide poll. Deamination and oxidation damages interfere with cell�s vital reactions. Inosine triphosphate pyrophosphatase (ITPA), an evolutionary conserved enzyme, plays a critical role in elimination of non-canonical bases. In human genome, the ITPA gene is located on chromosome 20 short arm and tran...

Background: MicroRNAs are small noncoding RNAs that regulate gene expression and involve in many cellular and physiological mechanisems. Recent studies have revealed that dysregulation of microRNAs might contribute to autoimmune disorders such as multiple sclerosis. Based on these findings, we examined the potential role of miR-320 isoforms, miR-320-3p and miR-320-5p, in the context of autoimmu...

Journal: :The Journal of biological chemistry 2004
Andreas Giessl Alexander Pulvermüller Philipp Trojan Jung Hee Park Hui-Woog Choe Oliver Peter Ernst Klaus Peter Hofmann Uwe Wolfrum

Photoisomerization of rhodopsin activates a heterotrimeric G-protein cascade leading to closure of cGMP-gated channels and hyperpolarization of photoreceptor cells. Massive translocation of the visual G-protein transducin, Gt, between subcellular compartments contributes to long term adaptation of photoreceptor cells. Ca(2+)-triggered assembly of a centrin-transducin complex in the connecting c...

Journal: :Mechanisms of Development 2001
Kornélia Szabó Gáspár Jékely Pernille Rørth

The small GTPase Ras is critical for regulation of growth and differentiation during development. The mammalian protein RIN1 is a potential Ras effector protein, which can also interact with the Abelson tyrosine kinase. However, its biological function is unknown. We have identified the Drosophila homologue of RIN1, called sprint, for SH2, poly-proline containing Ras interactor. The sprint locu...

2010
Yanhua Bai Misa Nakamura Gengyin Zhou Yaqiong Li Zhiyan Liu Takashi Ozaki Ichiro Mori Kennichi Kakudo

Periostin is an extracellular matrix protein. Five isoforms of human periostin cDNA have been reported, but the expression of periostin isoforms in the human thyroid tissue is by far unknown. A group of primer sets were designed to amplify the full length of cDNA sequence of periostin. Using human thyroid carcinoma and their paired non-neoplastic tissues together with anaplastic thyroid carcino...

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