In the title mol-ecule, C(19)H(14)ClN(3)O, the quinoline and quinazoline ring systems form a dihedral angle of 80.75 (4)°. In the crystal, the mol-ecules are linked by pairs of C-H⋯N hydrogen bonds into centrosymmetric dimers, generating R(2) (2)(6) ring motifs. The structure is further stabilized by C-H⋯π inter-actions and π-π stacking inter-actions [centroid-centroid distances = 3.7869 (8) an...

The title compound, C(13)H(18)O(4), is an inter-mediate product in the synthesis of quinazoline derivatives. Crystal structure analysis shows that the benzene-butoxy C(ar)-O-C-C torsion angle is 175.3 (2)° and that the benzene-methoxycarbonyl C(ar)-C-O-C torsion angle is 175.2 (2)°. Torsion angles close to 180° indicate that the molecule is almost planar.

In the mol-ecule of the title compound, C17H16N2OS, the almost planar methyl-sulfanylquinazoline group [the methyl C atom deviates by 0.032 (2) Å from the plane through the ring system] forms an inter-planar angle of 76.26 (4)° with the plane of the phenyl group. An intra-molecular O-H⋯N hydrogen bond is present between the quinazoline and hy-droxy groups. In the crystal, mol-ecules are stacked...

In the title compound, C20H21N3O2·H2O (EQR·H2O), the quinazoline ring system forms dihedral angles of 53.1 (1) and 85.6 (1)° with the phenyl ring and the amide link, respectively. In the crystal, O-H⋯O hydrogen bonds link two EQR and two water mol-ecules into a centrosymmetric R 4 (4)(18) ring motif. N-H⋯O hydrogen bonds further link these hydrogen-bonded fragments into columns extending in [010].

The reaction of heteroaryl chlorides in the pyrimidine, pyrazine and quinazoline series with amines in water in the presence of KF results in a facile SN Ar reaction and N-arylation. The reaction is less satisfactory with pyridines unless an additional electron-withdrawing group is present. The results showed that the transition-metal-free SN Ar reaction not only compares favourably to palladiu...

A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-arylox...

New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent ...

In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A silyl-Hilbert-Johnson reaction of six quinazoline-2,4-(1H,3H)-dione-like base moieties with a suitable ribofuranosephosphonate afforded the desired analogues after full deprotection. In contrast to the parent 5-(4-fluoropheny)uridine pho...

The aim of this study was to evaluate the in vitro and vivo antimicrobial activity a new pyrimidine derivative against Staphylococcus aureus . assessment compound 3 3-(2-Phenyl-2- oxoethyl)quinazoline-4(3H)-one performed using test culture S. strain isolated from patients’ sputum by serial dilutions meat-peptone broth, followed formation sequences with concentration 128 mcg/ml; 64 32 16 8 4 2 1...

2-Sulfanyl-6-(2-thienyl)pyridine-3-carbonitrile, 1-Amino-6-(5-bromo-benzofuran-2-yl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile, thieno[2,3-b]pyridins, pyrimidino[4',5':4,5] thieno[2,3-b]pyridine, quinazoline and carbamate derivatives were synthesized from sodium 3-(5-bromobenzofuran-2-yl)-3-oxoprop-1-en-1-olate with. The newly synthesized compounds were elucidated by elemental analysis, spectra...