Metformin is currently prescribed worldwide to treat type 2 diabetes, and therefore, radiolabeled [(14) C] metformin is often prepared for clinical comparisons of new drug candidates. Prior to using the radiolabeled metformin, the purity needs to be determined to ensure the quality of the material. While typical reversed-phase LC methods are often the first choice for purity analysis, they are ...

backgrounds: bleomycin (blm) has been labeled with radioisotopes and widely used in therapy and diagnosis. in this study blm was labeled with [62zn] zinc chloride for oncologic pet studies. materials and methods: the complex was obtained at the ph=2 in normal saline at 90 ° c in 60 min. radio-tlc showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). stability of complex ...

in this study, production, quality control and biodistribution studies of 166ho-zoledronate have been presented as a possible bone marrow ablative agent. ho-166 chloride was produced by thermal neutron irradiation of natural 165ho(no3)3 samples. 166ho-zoledronate complex was prepared by adding the desired amount of zoledronate solution (0.2 ml, 150 mg/ml in 1 m naoh) to appropriate amount of th...

introduction: due to interesting therapeutic properties of 46sc and antineoblastic antibiotic, bleomycin (blm), 46sc-bleomycin (46sc-blm) was developed as a possible therapeutic compound. methods: in this work, sc-46 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of natural metallic scandium sample followed by dissolution in acidic media  as a substitute for 47sc in radiol...

introduction: bleomycins are dna-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as yb-175. in this work the development of yb-175 bleomycin (175yb-blm) has been reported. methods: yb-175 chloride was obtained by thermal neutron irradiation (3 × 1013 n.cm-2.s-1) of natural yb2o3 samples at various neutron fluxes and irradiation time...

6-Deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF) is a promising PET radiotracer for imaging GLUT5 in breast cancer. The present work describes GMP synthesis of 6-[(18)F]FDF in an automated synthesis unit (ASU) and dosimetry calculations to determine radiation doses in humans. GMP synthesis and dosimetry calculations are important prerequisites for first-in-human clinical studies of 6-[(18)F]FD...

OBJECTIVE Our study evaluated the accuracy and reliability of 3 radiochemical purity (RCP) measurement methods of 99mTc-sestamibi. A regular-sized (1.0 cm x 9.0 cm) Whatman 31 ET Chr paper strip (regular 31 ET) also was included in our evaluation because of its ease in handling. METHODS The miniaturized and regular 31 ET methods were compared with the standard RCP testing method (aluminum oxi...

METHODS: Nineteen vials of tetrofosmin were radiolabelled with Tc and the percentages of the RCP were determined. Five different methods were compared with the standard RCP testing method (ITLC-SG, 2x20 cm): Whatman 3MM (1x10 cm) with acetone and dichloromethane (method 1); Whatman 3MM (1x10 cm) with ethyl acetate (method 2); aluminum oxide-coated plastic thin-layer chromatography (TLC) plate (...

Somatostatin analoges labeled with different radionuclides are able used for imaging and treatment of somatostatin receptor positive tumors. In this study Tyr³-Octreotide protected at lysine as an analoge of somatostatin was conjugated with bifunctional chelating agent 6-BOC-hydrazinopyridine-3-carboxylic acid (BOC-HYNIC) and after deprotecting of conjugate, purification was performed wit...