Helicobacter pylori is an important risk factor for gastric cancer, gastric ulcer, and duodenal ulcer, yet most infected persons do not develop disease. We examined two correlates of acquisition age, sibship size and birth order, to evaluate the hypothesis that early life acquisition of H. pylori is a risk factor for the development of these illnesses. In earlier nested case-control studies of ...

In this study, we examined rabbit gastric ulcer models that can serve as more clinically relevant models. Two types of ulcer model were studied: acetic acid-induced ulcers (AAU) and mucosal resection-induced ulcers (MRU). For AAU, rabbit gastric mucosa was exposed by median laparotomy and treated with bottled acetic acid. MRU was examined as a model for endoscopic mucosal resection (EMR). Norma...

AIM To explore the roles of nitric oxide synthase (NOS), heme oxygenase (HO) and cyclooxygenase (COX) in gastric ulceration and to investigate the relationships of the expression and activities of these enzymes at different stages of gastric ulceration. METHODS Gastric ulcers (kissing ulcers) were induced by luminal application of acetic acid. Gastric tissue samples were obtained from the ulc...

A previous study has demonstrated that locally administered growth factors such as epidermal growth factor, basic fibroblast growth factor and hepatocyte growth factor can accelerate healing of experimental gastric ulcers in rats. That study indicates that locally administered growth factors can exert potent biological effects resulting in enhanced gastric ulcers healing. However, the fate of i...

Recurrent, peptic ulcer following surgery has a 3% to 10% recurrence rate. Recurrence is due to one of the following causes: incomplete vagotomy, failure of gastric drainage, inadequate gastric resection, Zollinger-Ellison syndrome, hyperplasia of the antral gastric-secreting cells or due to use of nonabsorbable sutures. Lack of or incomplete vagotomy has been the most common cause. Gastric ulc...

The development of gap junctions in the human gastric mucosa has been examined to see if there is any relation to gastric ulcer. Freeze fracture replicas were prepared from the endoscopic biopsy specimens of 20 patients with gastric ulcer (15 men and five women, aged 49 (13) years) and seven healthy volunteers (four men and three women, aged 41 (19) years). Large fractured areas of lateral cell...

In this study ethanolic extract of Aegle marmelos was evaluated for its anti-ulcer activity against aspirininduced gastric ulcer in albino rats. Various biochemical parameters such as gastric volume, pH of gastric content, free acidity and total acidity, total carbohydrate content such as total protein, hexoses, hexosamine, fucose and sialic acid were estimated in alcoholic precipitate of gastr...

Experimental and clinical data have incriminated excess gastric acid secretion as an important factor in the development of duodenal ulcer. On the other hand, gastric ulcer is characteristically associated with normal to low levels of acid secretion, and mucosal resistance factors have been invoked to explain the pathogenesis. The purpose of this report is to summarize the evidence favouring th...

Objective: Biebersteinia multifida is one of the native plants of Iran and its root is used in folk medicine. This study aimed to evaluate the gastro-protective effect of the hydro-methanolic extract of this plant's roots against ethanol-induced gastric ulce...

Jasminum sambac is used in folk medicine as the treatment of many diseases. The aim of the present investigation is to evaluate the gastroprotective effects of ethanolic extracts of J. sambac leaves against acidified ethanol-induced gastric ulcers in rats. Seven groups of rats were orally pre-treated with carboxymethylcellulose (CMC) as normal group, CMC as ulcer group, 20 mg/kg of omeprazole a...