gene association studies are less appealing in cancer compared to autoimmune diseases. complexity, heterogeneity, variation in histological types, age at onset, short survival, and acute versus chronic conditions are cancer related factors which are different from an organ specific autoimmune disease, such as grave’s disease, on which a large body of multicentre data is accumulated. for years t...

Objective(s): Regulatory T cells, including CD4+CD25+Fox3+ and CD8+CD28- cells play an important role in regulating the balance between immunity and tolerance. Since multiple sclerosis is an inflammatory autoimmune disease, regulatory T cells are considered to be involved in its pathogenesis. In this study, we investigated the circulatory numbers of the two mentioned types of regulatory T cells...

We characterize the optimal regulatory policy to promote demand response in the electricity sector. Demand response arises when consumers reduce their purchases of electricity in times of peak demand, when the utility’s marginal cost of supplying electricity is relatively high. The optimal policy differs systematically from the policy in the U. S. Federal Energy Regulatory Commission’s (FERC’s)...

Starting from studying a melanoma patient with heterogenous response, In article 2100098, Lujun Shen, Ying Wu, and co-workers identified inducible regulatory T cells (iTregs) as key predictor of treatment response PD-1 inhibitor based immunotherapy in melanoma. Further analysis multi-omics data this special public datasets uncover the molecular features potential therapeutic targets iTregs.

The internet has transformed the manner of conducting commercial transactions and has created regulatory gaps. These regulatory gaps may impact the effective development of electronic commerce. Attempts are being made to regulate electronic contracts both at the national and international level. The present research analyses these attempts, in particular the Electronic Transaction Legislation ...

the sulfur regulatory circuit of the filamentous fungus, neurospora crassa, consists of a set of unlinked structural genes which encode sulfur catabolic and two major regulatory genes which govern their expression. the cys-3 regulatory gene encode a transacting regulatory protein which activates the expression of cys-14 and ars, whereas the other regulatory genes scon-l and scon-2 appear to act...