The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...

The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...

In order to improve the operation and maintenance (O&M) of offshore wind turbines, a new Petri net (PN)-based turbine model is developed in this paper simulate O&M activities an farm. With aid PN developed, three potential strategies are studied. They (1) carrying out periodic components at different frequencies according their specific reliability features; (2) conducting full inspecti...

A complex repairable system generally adopts multi-grade preventive maintenance. The optimization of maintenance decision making is usually regarded as a complex mathematical problem. This study proposes a three-grade preventive maintenance optimization method for complex repairable system based on field failure data. Specifically, all failures are classified into three categories: minor, moder...

Software maintenance is responsible for as much as two thirds of the cost of any software, and is consequently an important research area. In this paper we focus on the change propagation problem: given a primary change that is made in order to meet a new or changed requirement, what additional, secondary, changes are needed? We build on previous work that has proposed to use a BDI (belief-desi...

at many circumstances, in heat exchange processes several exchangers were used with different cost laws due to their pressure ratings, materials of construction and exchange3r types. in such circumstances traditional methods of pinch technology can not be led to minimum total annual cost may cause some other disadvantages like more complexity or higher maintenance. in this research work a new a...

Is there maintenance in complex biological systems or life is a continuous space-time drift? The emphasis that in the past years has been placed on tissue repair is, at least, misplaced since this property coincides with the same strategy that handles development and maintenance, a strategy that is broadly adaptive. It is not a mere philosophical question, since it deals with limited cellular r...

Objective: Majorproducers consider quality as a major criterion in decision making.Quality characteristics are affected by maintenance and repair decisions. In this study, a model is developed to determine significant measurements of production equipment affecting the quality of a continuous product to identify which measurements are more critical in terms of quality. Methods: Diversity of par...