Early in 1961 a city-wide oral poliomyelitis vaccination program was under-taken in the city of Middletown, Connecticut by the and his staff. A description of various aspects of this so-called mass vaccination project follows in the papers that make up this issue of THE YALE JOURNAL OF BIOLOGY AND MEDICINE. In the Middletown program some 10,000 children under the age of 18 received oral poliovi...