نتایج جستجو برای: scar contraction

تعداد نتایج: 72209  

2013
S. Murthy M. K. Gautam Shalini Goel V. Purohit H. Sharma R. K. Goel

Wound healing effects of 50% ethanol extract of dried whole plant of Bacopa monniera (BME) was studied on wound models in rats. BME (25 mg/kg) was administered orally, once daily for 10 days (incision and dead space wound models) or for 21 days or more (excision wound model) in rats. BME was studied for its in vitro antimicrobial and in vivo wound breaking strength, WBS (incision model), rate o...

2012
Stephanie Clement-Guinaudeau Jonathan Suever Antonello D'Andrea Frits Prinzen Michael Lloyd Angel R Leon John N Oshinski

Background One third of the patients selected by the standard criteria to receive a cardiac resynchronization therapy (CRT) do not positively respond by clinical or functional outcome parameters. A large scar burden by late Gadolinium enhancement cardiac magnetic resonance (CMR) has been associated with non-response to CRT. However, CMR parameters, which predict response in nonischemic patients...

2012
Douwe M. Veltman Jason S. King Laura M. Machesky Robert H. Insall

Under normal conditions, the Arp2/3 complex activator SCAR/WAVE controls actin polymerization in pseudopods, whereas Wiskott-Aldrich syndrome protein (WASP) assembles actin at clathrin-coated pits. We show that, unexpectedly, Dictyostelium discoideum SCAR knockouts could still spread, migrate, and chemotax using pseudopods driven by the Arp2/3 complex. In the absence of SCAR, some WASP relocate...

Journal: :Circulation. Arrhythmia and electrophysiology 2013
Takeshi Sasaki Christopher F Miller Rozann Hansford Vadim Zipunnikov Menekhem M Zviman Joseph E Marine David Spragg Alan Cheng Harikrishna Tandri Sunil Sinha Aravindan Kolandaivelu Stefan L Zimmerman David A Bluemke Gordon F Tomaselli Ronald D Berger Henry R Halperin Hugh Calkins Saman Nazarian

BACKGROUND The association of local electrogram features with scar morphology and distribution in nonischemic cardiomyopathy has not been investigated. We aimed to quantify the association of scar on late gadolinium-enhanced cardiac magnetic resonance with local electrograms and ventricular tachycardia circuit sites in patients with nonischemic cardiomyopathy. METHODS AND RESULTS Fifteen pati...

2014
Suk Joon Oh Jihoon Yang Seon Gyu Kim Sung Won Jung Sung Hoon Koh

Scar revision is one of the fundamental techniques in the field of plastic and reconstructive surgery. Local flaps, such as a Z-plasty, W-plasty, or geometric broken-line closure, have been used for scar revision. Camouflaging a scar during scar revision for marginal scars from skin grafts and flaps, trapdoor scars, and linear scars is difficult. We describe our experience with the use of modif...

Journal: :Circulation. Arrhythmia and electrophysiology 2011
Paul A Scott John M Morgan Nicola Carroll David C Murday Paul R Roberts Charles R Peebles Stephen P Harden Nick P Curzen

BACKGROUND Characterization of sudden cardiac death (SCD) risk remains a challenge in the application of implantable cardioverter-defibrillator (ICD) therapy. Late gadolinium enhancement cardiac MRI (LGE-CMR) can accurately identify myocardial scar. We performed a retrospective, single-center observational study to evaluate the association between the extent and distribution of left ventricular...

2017
Preeti Maan Kuldeep Singh Yadav Narayan Prasad Yadav

BACKGROUND The paste of stem bark of Azadirachta indica (AI) has been traditionally used on wound and scar for rapid healing in Bundelkhand region of India. OBJECTIVE In the present investigation, wound healing potential of different extracts of stem bark of AI was explored in mice model. MATERIALS AND METHODS To study the wound healing properties in small animal model, the excision and inc...

Journal: :The American journal of pathology 1988
R J Eddy J A Petro J J Tomasek

Contraction is an important phenomenon in wound repair and hypertrophic scarring. Studies indicate that wound contraction involves a specialized cell known as the myofibroblast, which has morphologic characteristics of both smooth muscle and fibroblastic cells. In order to better characterize the myofibroblast, the authors have examined its cytoskeleton and surrounding extracellular matrix (ECM...

2010
U. M. Dhanalekshmi P. N. Reddy

The aim of this study is to explore the wound healing and antimicrobial effects of crude ethanolic extract of the whole plant of Evolvulus alsinoides L., (Convolvulaceae). Excision wounds were created in Wistar rats and the area of skin wound in the experimental group was dressed with crude ethanolic extract, while the animal in the control group was dressed with normal saline. The wound area w...

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