Hot spots are energetically important residues at protein interfaces and they are not randomly distributed across the interface but rather clustered. These clustered hot spots form hot regions. Hot regions are important for the stability of protein complexes, as well as providing specificity to binding sites. We propose a database called HotRegion, which provides the hot region information of t...

The steroid and xenobiotic-responsive human pregnane X receptor (PXR) binds a broad range of structurally diverse compounds. The structures of the apo and ligand-bound forms of PXR are very similar, in contrast to most promiscuous proteins that generally adapt their shape to different ligands. We investigated the structural origins of PXR's recognition promiscuity using computational solvent ma...

We present low-resolution spectrophotometric optical observations of the eclipsing nova-like cataclysmic variable SW Sex, the prototype of the SW Sex stars. We observed the system when it was in an unusual low state. The spectrum is characterized by the presence of strong Heii and Civ emission lines as well as the normal single peaked Balmer emission lines. The radial temperature profile of the...

A new methodology called “sensor-based knowledge discovery”, which utilizes wearable sensors and statistical analysis, is proposed and evaluated. This methodology facilitates identifying new knowledge that can improve business outcome. It utilizes wearable sensors to unobtrusively capture people’s location, motion, and social interaction with others. The captured data is converted into multidim...

We consider a convex polygonal heat conductor whose inscribed circle touches every side of the conductor. Initially, the conductor has constant temperature and, at every time, the temperature of its boundary is kept at zero. The hot spot is the point at which temperature attains its maximum at each given time. It is proved that, if the hot spot is stationary, then the conductor must satisfy two...

The temperature and composition of Earth's mantle control fundamental planetary properties, including the vigor of mantle convection and the depths of the ocean basins. Seismic wave velocities, ocean ridge depths, and the composition of mid-ocean ridge basalts can all be used to determine variations in mantle temperature and composition, yet are typically considered in isolation. We show that c...

We report new near-infrared, long-baseline interferometric observations at the AU scale of the pre-main-sequence star FU Orionis with the PTI, IOTA and VLTI interferometers. This young stellar object has been observed on 42 nights over a period of 6 years from 1998 to 2003. We have obtained 287 independent measurements of the fringe visibility with 6 different baselines ranging from 20 to 110 m...

We have examined the directional cross-correlation of statistical ‘hot-spots’ between a Northern Sky TeV Gamma Ray Survey by the Milagro Observatory and a similar survey by the Tibet Array. We find the directions of these hot-spots are angularly uncorrelated between the two surveys for large angular separations (∆θ > 4), but there appears to be a statistically significant correlation between ho...

Acoustic behavior of lipid-coated microbubbles has been widely studied, which has led to several numerical microbubble dynamics models that incorporate lipid coating behavior, such as buckling and rupture. In this study we investigated the relationship between microbubble acoustic and lipid coating behavior on a nanosecond scale by using fluorescently labeled lipids. It is hypothesized that a l...

This paper presents how hot spot detection methods can be extended to allow for temporal dimensions. Major concerns are how temporal dimension is incorporated into the framework of point pattern analysis, while maintaining the capability of multi-scale analysis. The study elaborates on expanding the scope of (space) K function in order to count time in the analysis. With the explicit treatment ...