BACKGROUND Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance (IR) and related disorders. Elevated serum levels of cellular adhesion molecules (CAMs) reflect low-grade chronic inflammation and have been associated with several insulin-resistant states. The objective of this study is to investigate whether soluble inflammatory markers [soluble intercel...

Although cellular adhesion molecules (CAMs) are hypothesized to play an important role in atherogenesis, the relationship between CAMs and systemic atherosclerosis is uncertain. Among 92 outpatients (48 men; mean+/-SD age, 65+/-9 years), we evaluated the association of soluble vascular CAM-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) with carotid intimal-medial thickness (IMT), a...

The effect of angiotensin type 1 receptor blockade on adhesion molecules in patients with IgA nephropathy Sir, Various studies have linked inflammation and endothe-lial dysfunction in patients with chronic renal disease [1]. Plasma levels of adhesion molecules [soluble intracellu-lar adhesion molecule-1 (sICAM) and soluble vascular adhesion molecule-1 (sVCAM)] are markers of endothelial dysfunc...

Endothelial dysfunction is thought to be a central pathogenic feature in preeclampsia on the basis of elevated adhesion molecules. The aim of the present study was to compare the levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1) and E-selectin (sE-selectin) in sera of normal and preeclamptic pregnancies. We studied the serum levels of sVC...

BACKGROUND The degree of inflammatory reaction and leucocyte trafficking during acute pyelonephritis has been related to the risk of developing renal parenchymal scarring. Adhesion molecules play a central role in leucocyte recruitment during inflammation. AIMS (1) To determine whether circulating and urinary concentrations of E-selectin and intercellular adhesion molecule 1 (ICAM-1) were abn...

729 AN INFLAMMATORY STATE IS KNOWN TO EXIST IN SLEEP DISORDERS.1,2 INTERLEUKIN-6 (IL-6), FOR EXAMPLE, IS AN INFLAMMATORY CYTOKINE THAT IS elevated in sleep apnea and narcolepsy.3-5 Better sleep is associated with decreased daytime secretion of IL-6, whereas disturbed nocturnal sleep is associated with increased daytime IL-6 levels.6 Other markers of inflammation, including plasma endothelin-1 (...