Silybum marianum is a medicinal plant that produces silybins A and B, which exhibit liver-protective activities. The He–Ne laser pre-sowing seed treatment has been used as physical biostimulator in numerous plants to promote germination, growth, secondary metabolite production. Thus, this study, at 632.8 nm was irradiate S. seeds with the aim of promoting growth well enhancing production silybi...

Silybin (SB), a natural flavonoid isolated from Silybum marianum , has been used to treat hepatic fibrosis in clinical settings and as dietary supplement, because of its hepatoprotective potential. Numerous studies have shown that SB also exerts promising anticancer effects; however, the targets underlying mechanism were unclear. Herein, we found significantly inhibited proliferation non-small ...

Purpose: To develop a nanosuspension drug delivery system to enhance the dissolution rate of Silybum marianum seeds extract.
 Methods: Central composite design was used study effect input variables (stabilizer plant extract ratio, antisolvent solvent stirring time) on dependent (mean particle size, polydispersity index (PDI) and zeta potential). The optimized formulation characterized by S...