pemphigus vulgaris (pv) is one of the most common and studied autoimmune disorders of skin. the knock down of desmogleins in the skin by igg antibodies will eventually leads to mucocutaneous problems in both genders. targeting the cardinal molecules involved in the pathways of immune response is the main goal of given therapy. with regard to the side effects of long term use of immunosuppressiv...

abstract background: hope is the most important factor in diabetic patients’ life. the level of hope may be changing among these individuals as a result of chronic nature of diabetes and its complications. when the level of hope increases among these patients, they can resist against physical and psychological complications of diabetes more, accept the treatment better, enjoy life more, and ada...

background: primary dysmenorrhoea without any specific pelvic disease is one of the common complaints in women`s medicine. the general purpose of this research is to define the effects of 12-week aquatic exercises on nonathletic girls’ primary dysmenorrhoea. materials and methods: this quasi-experimental was conducted on 40 nonathletic girls aged 18-25 years. data gathering tools were: evaluati...

objectives analysis of ns5a polymorphisms in hcv genotype 1b pre-treatment serum samples from estonian patients and their effect on the treatment response. patients and methods twenty-nine complete ns5a sequences obtained from patients with chronic hcv-1b infection who had received combined therapy with pegifnα-2a/rbv were analyzed and compared with the prototype strain hcv-j. twelve patients a...

objectives: the main aim of this study was to determine the effects of integrative reminiscence therapy on signs and symptoms of depression in the institutionalized elderly. methods & materials: this study was an experimental study with pre-test and post-test along with control group. the statistical society in this study consisted of all elderly adults residing in centers of isfahan. sample se...

the cognitive behavioral interventions based on the transdiagnostic approach for emotional disorders have received useful empirical supports in recent years. most of the researches on this area have been conducted without any control group. moreover, little information about comparative effectiveness has reported. the current study was compared transdiagnostic group therapy with classical cogni...

the main goal in endodontic treatment is to eradicate or at least reduce intraradicular microbial population to levels that are more compatible with periapical lesions healing process. since endodontic infections are polymicrobial in nature, intraradicular survival of endodontic microbiota and their pathogenic properties are influenced by a combination of their virulence factors. the purpose of...

background: suppressive therapy with levothyroxine for reducing the size of thyroid nodules has not been really accepted. the purpose of this study was to assess the effect of levothyroxine on the size of benign thyroid nodules. methods: forty patients with confirmed benign nodule were randomly divided into two groups. group i received 50?g/day levothyroxin for six months but group ii did not t...

background and objectives: significant progress has been made in treatment of hemophilia. ex-vivo gene therapy is going popular due to the capability of this method in using isogenic cells for genetic manipulation and reintroducing them into same host after proliferation. most gene therapy techniques use viral vectors, which usually harbor a strong and non-specific promoter (e.g. cmv early prom...