BACKGROUND Brief sevoflurane exposure and washout (sevoflurane preconditioning [SPC]) before 30-min global ischemia at 37 degrees C is known to improve cardiac function, decrease cytosolic [Ca(2+)] loading, and reduce infarct size on reperfusion. It is not known if anesthetic preconditioning (APC) applies as well to hypothermic ischemia and reperfusion and if K(ATP) channels are involved. The a...

Canine microsomal signal peptidase activity was previously isolated as a complex of five subunits (25, 22/23, 21, 18, and 12 kDa). Two of the signal peptidase complex (SPC) subunits (23/23 and 21 kDa) have been cloned and sequenced. One of these, the 21-kDa subunit, was observed to be a mammalian homolog of SEC11 protein (Sec11p) (Greenburg, G., Shelness, G. S., and Blobel, G. (1989) J. Biol. C...

How dividing cells monitor the effective transmission of genomes during mitosis is poorly understood. Budding yeast use a signaling pathway known as the spindle position checkpoint (SPC) to ensure the arrival of one end of the mitotic spindle in the nascent daughter cell. An important question is how SPC activity is coordinated with mother-daughter polarity. We sought to identify factors at the...

The escalating demands on the development of software products require software organizations to produce mature software processes that are capable of providing the required levels of quality and productivity. The implementation of statistical process control (SPC) in performance process analysis uses data collected during the course of the project to analyze the behavior of organization proces...

This paper develops a new multivariate statistical process control (SPC) methodology based on adapting the LASSO variable selection method to the SPC problem. The LASSO method has the sparsity property that it can select exactly the set of nonzero regression coefficients in multivariate regression modeling, which is especially useful in cases when the number of nonzero coefficients is small. In...

BACKGROUND Arterial hypertension is a common disorder that affects around 9 million adults in Poland. Single-pill combinations (SPCs) for the treatment of arterial hypertension have significant advantages over the free combinations, resulting in lower risk of cardiovascular events and lower consumption of medical resources. The current ESC/ESH 2013 guidelines for the first time recommend treatm...

In recent years, the integration of Statistical Process Control (SPC) and Engineering Process Control (EPC) has received considerable attentions due to the superiority for the process improvement. However, a drawback of the integration of SPC and EPC may be encountered for monitoring a process. Because EPC would compensate for the effects of underlying disturbances, the disturbance patterns cou...

Statistical process control (SPC) is a powerful technique for monitoring, managing, analyzing and improving process performance by statistical methods. Unfortunately, LCD industry cannot control key factors in the application process, and do not invest adequately in resources. Therefore, the performance matrix is adopted to locate those objective items outside the appropriate performance zones ...

Small cell lung cancer (SCLC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we assessed the effect of Trp53 and Rb1 inactivation in distinct cell types in the adult lung using adenoviral vectors that target Cre recombinase to Clara, neuroendocrine (NE), and alveolar type 2 (SPC-expressing) cells. Using these cell type-restricted Adeno-Cre vi...