Ceftazidime-avibactam has activity against Pseudomonas aeruginosa and Enterobacteriaceae expressing numerous class A and class C β-lactamases, although the ability to inhibit many minor enzyme variants has not been established. Novel VEB class A β-lactamases were identified during characterization of surveillance isolates. The cloned novel VEB β-lactamases possessed an extended-spectrum β-lacta...

Speech sounds occupy 8 kHz or more of bandwidth. However, current public telephone networks limit the speech bandwidth to 300–3400 Hz. Telephone speech is characterized by thin and muffled sounds, and degraded speaker identification. We describe an algorithm which generates the missing highband components from the narrowband speech signal. The algorithm is based on three acoustic-phonetic class...

Given a set of n points in the plane, any β-skeleton and [γ0, γ1]-graph can be computed in quadratic time. The presented algorithms are optimal for β values that are less than 1 and [γ0, γ1] values that result in non-planar graphs. We show a numerically robust algorithm that computes Gabriel graphs in quadratic time and degree 2. We finally show how a β-spectrum can be computed in optimal O(n2)...

In this paper we study the operator Hβ = −∆− βδ(· − Γ) in L2(R2), where Γ is a smooth periodic curve in R2. We obtain the asymptotic form of the band spectrum of Hβ as β tends to infinity. Furthermore, we prove the existence of the band gap of σ(Hβ) for sufficiently large β > 0. Finally, we also derive the spectral behaviour for β → ∞ in the case when Γ is non-periodic and asymptotically straight.

Escherichia coli is a common cause of infections in companion animals. In recent years the increasing prevalence of resistance to β-lactams, including extended-spectrum cephalosporins, antimicrobials frequently used in small animal veterinary practice, was observed in canine isolates of E. coli. The aim of this study was to detect and to characterize extended-spectrum β-lactamases (ESBLs) produ...

In a multicenter, multinational observational study that included neutropenic patients with bloodstream infections by extended-spectrum-β-lactamase-producing species, Gudiol et al. (Antimicrob. Agents Chemother. 61:e00164-17, 2017, https://doi.org/10.1128/AAC.00164-17) demonstrated that β-lactam/β-lactamase inhibitors are effective treatment options. A review of this work, however, reminds us t...