The possibility of spherical agglomeration was investigated for two active pharmaceutical ingredients from different classes the Biopharmaceutics Classification System. effects batch crystallization solvent systems on granulometric properties and structures dronedarone hydrochloride ceritinib were investigated. Light stereomicroscopy used to determine size shape agglomerates, while X-ray powder...

Fatty acid butyl esters were synthesized from sunflower oil with 1-butanol using a homogeneous Rhizomucor miehei lipase in a biphasic organic (triglyceride, 1-butanol, hexane)- water (with enzyme) system in a continuous setup consisting of a cascade of a stirred tank reactor and a continuous centrifugal contactor separator (CCCS), the latter being used for integrated reaction and liquid-liquid ...

As high-grade and easily exploitable copper ores have been getting depleted, the development of flotation techniques for with low-grade small grain size is becoming an important issue. To process these kinds ores, fine grinding essential to achieve sufficient liberation; however, rate finely ground minerals (<5 µm) substantially low due collision probability between air bubbles mineral particle...

Spherical colloidal crystals are three-dimensional periodic arrays of monodisperse colloidal particles with a spherical geometry. The spatial periodicity of the refractive index of the colloidal crystalline arrays results in an optical stop band and, hence, they act as photonic crystals in the optical regime. In contrast to conventional film-type colloidal crystals where the crystals are aligne...

When a granular material such as sand is mixed with a certain amount of liquid, the surface tension of the latter bestows considerable stiffness to the material, which enables, for example, sand castles to be sculpted. The geometry of the liquid interface within the granular pile is of extraordinary complexity and strongly varies with the liquid content. Surprisingly, the mechanical properties ...

The objective was to investigate the applicability and limitations of an approach for estimating particle size from powder dissolution measurement using as little as 50 microg of sample in 1 ml of buffer solutions. The powder dissolution profiles of five sparingly-soluble drugs (hydrochlorothiazide, phenazopyridine hydrochloride, 2-naphthoic acid, indomethacin, and dipyridamole) were evaluated ...

In this study, surface modification of iron (II, III) oxide Fe₃O₄ nanoparticles by oleic acid (OA) coating is investigated for the microablation of fat in a microchannel. The nanoparticles are synthesized by the co-precipitation method and then dispersed in organic solvent prior to mixing with the OA. The magnetization, agglomeration, and particle size distribution properties of the OA-coated F...

The main purpose of this work is the computational simulation of the sensitivity coefficients of the homogenized tensor for a polymer filled with rubber particles with respect to the material parameters of the constituents. The Representative Volume Element (RVE) of this composite contains a single spherical particle, and the composite components are treated as homogeneous isotropic media, resu...

We investigate the formation of GMCs in spiral galaxies through both agglomeration of clouds in the spiral arms, and self gravity. The simulations presented include twofluid models, which contain both cold and warm gas, although there is no heating or cooling between them. We find agglomeration is predominant when both the warm and cold components of the ISM are effectively stable to gravitatio...