introduction: purkinje cell (pc) output displays a complex firing pattern consisting of high frequency sodium spikes and low frequency calcium spikes, and disruption in this firing behavior may contribute to cerebellar ataxia. riluzole, neuroprotective agent, has been demonstrated to have neuroprotective effects in cerebellar ataxia. here, the spectral analysis of pcs firing in control, 3-acety...

in order to study the sink-source physiological relationship, current photosynthesis, contribution and remobilization of assimilates to grain yield in wheat and triticale genotypes, a field experiment was conducted in iran, ahvaz area on 2003-4. treatments were two bread wheat (simareh and tawer), one durum wheat (showa) and two triticale (juvanillo92 and line 45) genotypes. grain weight change...

Recently, Wang and Hillen [Chaos 17 (3) (2007) 037108–037108] introduced a modified Keller-Segel model with logistic growth that exhibits complex spatiotemporal dynamics of spikes. These dynamics are driven by merging of spikes on one hand, and spike insertion on the other. In this paper we analyse the basic mechanisms that initiate and sustain these events. We identify two distinguished regime...

The neural mechanisms that enable recognition of spiking patterns in the brain are currently unknown. This is especially relevant in sensory systems, in which the brain has to detect such patterns and recognize relevant stimuli by processing peripheral inputs; in particular, it is unclear how sensory systems can recognize time-varying stimuli by processing spiking activity. Because auditory sti...

A network-centric view of brain function that is becoming more widely accepted would benefit from the directional interaction information that occurs between multiple neurons. Granger causality has been used previously to address this need, but previous methods can only operate on continuos-value data sets. This prevents it from being directly applied directly to neural spike train data so prev...

In examining spike trains, different models are used to describe their structure. The different models often seem quite similar, but because they are cast in different formalisms, it is often difficult to compare their predictions. Here we use the information-geometric measure, an orthogonal coordinate representation of point processes, to express different models of stochastic point processes ...

BACKGROUND Chronic extracellular recordings are a powerful tool for systems neuroscience, but spike sorting remains a challenge. A common approach is to fit a generative model, such as a mixture of Gaussians, to the observed spike data. Even if non-parametric methods are used for spike sorting, such generative models provide a quantitative measure of unit isolation quality, which is crucial for...

Accurate statistical models of neural spike responses can characterize the information carried by populations. But limited samples counts during recording usually result in model overfitting. Besides, current assume to be Poisson-distributed, which ignores fact that many neurons demonstrate over-dispersed spiking behaviour. Although Negative Binomial Generalized Linear Model (NB-GLM) provides a...