An interdisciplinary expert panel of medical and surgical specialists involved in the management of patients with potential spinal cord injuries (SCI) was assembled. Four key questions were created that were of significant interest. These were: (1) what is the optimal type and duration of pre-hospital spinal immobilization in patients with acute SCI?; (2) during airway manipulation in the pre-h...

The incidence of spinal cord injury (SCI) has been gradually increasing, and the treatment has troubled the medical field all the time. Primary and secondary injuries ultimately lead to nerve impulse conduction block. Microglia and astrocytes excessively accumulate and proliferate to form the glial scar. At present, to reduce the effect of glial scar on nerve regeneration is a hot spot in the r...

background: the failure of regeneration after spinal cord injury (sci) has been attributed to axonal demyelination and neuronal death. cellular replacement and white matter regeneration are both necessary for sci repair. in this study, we evaluated the co-transplantation of olfactory ensheathing cells (oec) and embryonic stem (es) cell-derived motor neurons (esmn) on contused sci. methods: oec ...

Tanshinone IIA serves as a coenzyme for certain biochemical reactions, exhibiting various pharmacological effects in the treatment of neurological diseases including spinal cord injury (SCI), however, its working mechanism SCI is not clear. Based on previous research, we believe that tanshinone promotes survival and repair nerves after through such anti-inflammatory, antioxidant, prevention cel...

Spinal cord injury (SCI) is the major cause of severe disability worldwide, which leads to neuron death, neuronal degeneration, and functional changes in spinal cord. Eucommia ulmoides extract (EUE) composed multiple iridoids phenols possesses anti-oxidative anti-inflammatory effects various pathologies. This study aims evaluate EUE on SCI underlying mechanisms. Male adult Sprague-Dawley rats (...

materials and methods: young adult sprague-dawley rats (200-250g) were assigned into one of the three different groups of control, sci, and adenovirus transfer (ad) (n=3/ group). control rats received no injury, nor any surgery. for sci rats, sci was produced by a 10g brass rod with a tip diameter of 2 mm which was dropped from a height of 12.5 mm onto exposed spinal cord at level of t10 with n...

Spinal cord injury during high-risk spinal deformity correction surgery occurs rarely despite best efforts to avoid it. Current neurophysiological monitoring strategies can only report an injury after it happens and some injuries fail to be captured intraoperatively. This catastrophic complication is usually irreversible. Using adult rats and an established spinal cord injury model, the objecti...

BACKGROUND Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal cord-the presumed basis of ensuing clinical impairment. OBJECTIVE The authors used a clinically viable, multimodal MRI protocol to quantify the axonal integrity of the cranial corticospinal tract (CST) and to establish...

Introduction: The number of traumatic spinal cord injuries associated with a fracture is on rise which compounded by in motor vehicle accidents the country. aim study was to assess frequency, cause, pattern, and demographic profile Bhutanese population. Methods: A retrospective conducted at National Referral Hospital from 2018 2020. records patients, treated for injury were reviewed. Results: O...