Sir: A new antibiotic which we named saphenamycin has been isolated from the cultured broth of a Streptomyces designated as MG314-hF8. The strain was classified as Streptomyces canarius by taxonomic study and direct comparison with a type culture1). In this paper, we report on the production, isolation, physical properties, structure, and biological activity of saphenamycin. Streptomyces canari...

The commonly accepted biosynthetic pathway1) leading to erythromycin A (I) requires that substrate for sugars (L-mycarose and Ddesosamine) attachment should be erythronolide B (IV). Once both sugars are linked to the aglycone, giving rise to erythromycin D, C-12 hydroxylation would occur resulting in erythromycin C production. Erythromycin C is further converted to erythromycin A by O-methylati...

There have been several investigations on the amino acid nutrition of Streptomyces. Early work on this subject by Waksman (1920) showed that certain single amino acids satisfied the nitrogen requirements of representative species of the genus Streptomyces. Considerable specificity in the ability to deaminate amino acids is exhibited by Streptomyces, as Woodruff and Foster (1943) have shown with...

The sequence of Streptomyces ambofaciens DSM 40697 was completely determined. The genome consists of an 8.1-Mbp linear chromosome with terminal inverted repeats of 210 kb. Genomic islands were identified, one of which corresponds to a new putative integrative and conjugative element (ICE) called pSAM3.

Streptomyces bacteria employ a newly-discovered cell type, the "explorer" cell, to rapidly colonize new areas in the face of competition.

Fungal diseases are currently a serious public health problem, due to the limited number of really effective principles, and the emergence of resistant strains to the polyenic antifungals. The aim of this study was to screen, for non-polyenic antifungals production by Actinobacteria, and to validate the screening program by characterizing the produced compounds. Actinobacteria isolates were tes...

Three plant-pathogenic isolates of Streptomyces spp., isolated from potatoes with common scab disease lesions in Korea, are described as novel species. Morphological and physiological properties of these isolates were distinct from those of previously described Streptomyces species. Strain S63(T) has yellow-white, smooth, cylindrical spores that are borne in monoverticillus flexuous spore-chain...

Antibiotic resistance is one of the most serious public health problems. Among bacterial resistance, β-lactam antibiotic resistance is the most prevailing and threatening area. Antibiotic resistance is thought to originate in antibiotic-producing bacteria such as Streptomyces. In this review, β-lactamases and penicillin-binding proteins (PBPs) in Streptomyces are explored mainly by phylogenetic...

In disease-suppressive soils, plants are protected from infections by specific root pathogens due to the antagonistic activities of soil and rhizosphere microorganisms. For most disease-suppressive soils, however, the microorganisms and mechanisms involved in pathogen control are largely unknown. Our recent studies identified Actinobacteria as the most dynamic phylum in a soil suppressive to th...

L-asparaginase is an anti-neoplastic agent used in the chemotherapy of lymphoblastic leukaemia. The present work deals with production of extra-cellular Lasparaginase from marine actinomycetes, using submerged fermentation. Marine actinomycete Streptomyces associated with marine spongeCallyspongia diffusa was isolated using specific ISP medium. Sponge-associated Streptomyces was character...