Here we report the draft genome sequence and annotation of A. veronii strain Ae52 isolated from the kidney of a morbund, septicaemic gold fish (Carassius auratus) in Sri Lanka. This clinical isolate showed resistance to multiple antimicrobials; amoxicillin, neomycin, trimethoprim-sulphonamide, chloramphenicol, tetracycline, enrofloxacin, erythromycin and nitrofurantoin. The size of the draft ge...

Trimethoprim is a synthetic compound which arrests the step in bacterial purine synthesis immediately succeeding that interfered with by sulphonamides. Acting alone it inhibits the growth of a wide range of bacteria in generally much lower concentrations than sulphonamides. Its action with a sulphonamide is strongly synergic and bactericidal.Studies are described of suitable cultural conditions...

my suggestion she was treated with nicotinic acid, which resulted in complete restoration of her sight. In March 1944 Hollis and' Baty (New England) reported a case of a 6 weeks' old child treated with sulphathiazole for meningitis due to the colon bacillus. The drug sterilized the cerebro-spinal fluid in a week but left the child totally blind. The report of Hollis and Baty's case reached me b...

GREEN, C. A. (I938) J. Path. Bact., 46, 382. JACOBSOHN, I., and SCHWARZ, J. (I932) Wien. klin. Wschr., 45, 306. JACOBY, A., WISHENGRAD, M., and KOOPMAN, J. (I938) Amer. J. Sy. Gon. and V. D., 22, 32. KOLLE, W., and HETSCH, H. (I934) "Experimental Bacteriology." 1, 388. (Eng. trans. London. Allen and Unwin.) OSBORN, T. W. B. (I937) " Complement or Alexin." (London. Milford. 55). OSMOND, T. E. (I...

of cases of smallpox, treated by me during the period 13th October, 1940 to 15th March, 1941, in the recent epidemic in Bezwada town. I do not claim any originality for the treatment. The chief interest of the investigation is that it combines the two remedial agents that have recently come to be recognized as of definite therapeutic value in this disease; namely, liver extract and the sulphona...

In this study, the serogroup and susceptibility patterns of Shigella and Salmonella spp. isolated from stool cultures were determined using standard laboratory procedures. Among the 76 Shigella isolates serogroup B (Sh. flexeneri) was the most prevalent species (54.0%) and among the 37 Salmonella strains serogroup B was also the most prevalent (81.1%). Antibiograms of Shigella and Salmonella sp...

Pyrazole-3-one compounds were designed on the basis of docking studies of previously reported antidiabetic pyrazole compounds. The amino acid residues found during docking studies were used as guidelines for the modification of aromatic substitutions on pyrazole-3-one structure. Depending on the docking score, the designed compounds were selectively prioritized for synthesis. The synthesized co...

The histological pictures associated with acute renal failure following abortion, incompatible blood transfusion, crush injuries, severe trauma, blackwater fever, sulphonamide intoxication, and many other conditions including burns have been described by various writers (Bratton, 1941 ; Dunn, Gillespie, and Niven, 1941; Bywaters and Beall, 1941; Bywaters and Dible, 1942; Erb, Morgan, and Farmer...

The faecal flora was studied in eight children admitted to hospital for treatment of a first urinary infection with sulphonamides. The original, sulphonamide-sensitive Escherichia coli organisms were found to disappear, to be replaced by other E. coli serotypes that were almost invariably resistant to sulphonamides. Some of these serotypes carried R-factors for multiple antibiotic resistance.Po...