Abstract In this pilot study, we proposed an algorithm to use thromboelastography platelet mapping (TEG-PM) as effective preoperative function assessment tool in coronary artery bypass graft surgery (CABG) reduce the transfusion requirement by determining timing of patients who are on dual antiplatelet therapy (DAPT). Total 15 elective CABG were receiving DAPT tested TEG-PM assay after 72 hours...

INTRODUCTION Thromboelastography (TEG) is a technique that measures coagulation processes and surveys the properties of a viscoelastic blood clot, from its formation to lysis. AIM To determine the possible hypercoagulability state and the effect of antithrombotic prophylaxis on thromboelastogram results and development of venous thrombosis during laparoscopic fundoplication. MATERIAL AND ME...

Central to the pathogenesis of ischaemic stroke are the normally protective processes of platelet adhesion and activation. Experimental evidence has shown that the ligand-receptor interactions in ischaemic stroke represent a thrombo-inflammatory cascade, which presents research opportunities into new treatment. However, as anti-platelet drugs have the potential to cause severe side effects in i...

OBJECTIVES the purpose of this study was to evaluate the association of the percentage of platelet inhibitory response to clopidogrel as assessed by modified thromboelastography with bleeding and transfusion requirement after off-pump coronary artery bypass graft (OPCABG) surgery. BACKGROUND Interindividual variability of clopidogrel responsiveness may influence bleeding and transfusion requi...

OBJECTIVES Thromboembolic events are the major factor affecting the prognosis of patients with chronic kidney disease (CKD). Haemostatic alterations are possible causes of these complications, but their roles remain poorly characterised. In the prospective observational study, we investigated the entire coagulation process in patients with CKD to elucidate the mechanisms of their high thromboem...

BACKGROUND In people, studies have shown that resistance to fibrinolysis could be a contributing factor to thrombosis. Tissue-plasminogen-activated (t-PA) thromboelastography (TEG) has been used to evaluate endogenous fibrinolytic potential. In dogs, TEG has been used for the diagnosis of various hemostatic disorders, but studies evaluating fibrinolysis are limited. Investigations into the pote...

Clinical coagulopathy frequently occurs in the presence of hypothermia. The primary purpose of this study was to investigate the effects of hypothermia on clotting protein fibrinogen metabolism and on coagulation function in a swine model. Twelve pigs were randomly allocated into control and hypothermia groups. Hypothermia of 32 degrees C was induced using a blanket with circulating water at 4 ...

We developed a complex combat-relevant model of abdominal and extremity trauma, hemorrhagic shock, hypothermia, and acidosis. We then simulated injury, preoperative, and operative phases. We hypothesized that this model is reproducible and useful for randomized multicenter preclinical trials. Yorkshire swine were anesthetized, intubated, and instrumented. They then underwent femur fracture, 60%...

Learning Objectives: 1. Understand mechanism of Rapid TEG, Platelet Mapping and ROTEM as compared to classic Thromboelastography 2. Understand applications of Platelet mapping in the clinical setting 3. Describe clinical application and evidence for using Rapid TEG 4. Discuss how these modified POC tests fit into current transfusion models Introduction: This syllabus will attempt to provide th...