OBJECTIVE To determine reference values for kaolin-activated thromboelastography in echocardiographically normal cats. ANIMALS 30 healthy cats without evidence of cardiomyopathy on echocardiographic examination. PROCEDURES All cats underwent echocardiographic examination, the findings of which were reviewed by a board-certified cardiologist. Cats that struggled (n = 10) received mild sedati...

UNLABELLED The monoclonal antibody fragment c7E3 Fab (ReoPro), by binding to platelet surface fibrinogen receptors (glycoprotein, GPIIb/IIIa), inhibits platelet aggregation and its interaction with fibrinogen. In this study, we used thromboelastography with ReoPro to evaluate the independent contribution of fibrinogen and platelets to clot strength. Thromboelastography was performed in 21 healt...

background:: hypercoagulability has been reported in primary brain tumors which can lead to thrombotic complications.hydroxyethyl starch (hetastarch) is a synthetic colloid solution with adverse effects on blood coagulation. the aim of this study was to evaluate the protective effect of hetastarch in reducing thromboembolic events in these patients. materials and methods: in a double-blinded cl...

Background. The Molecular Adsorbent Recirculating System (MARS) has been shown to clear albumin-bound toxins from patients with liver failure but might cause bleeding complications potentially obscuring survival benefits. We hypothesized that monitoring clotting parameters and bed-side thromboelastography allows to reduce bleeding complications. Methods. Retrospective analysis of 25 MARS sessio...

Neurosurgery requires the use of osmotic agents to reduce intracranial pressure which can adversely affect coagulation. Thromboelastography provides early indicator of derangement of coagulation. A prospective, non randomized pilot study was conducted to compare the effect of administration of either mannitol or hypertonic saline and when combined with hydroxy ethyl starch on coagulation and pl...

Laboratory evaluation of bleeding disorders has been performed with the standard clotting assays such as the PT and PTT for several decades. Our improved understanding of the process of blood coagulation has now revealed the important role played by the cellular elements such as platelets, monocytes and red blood cells. The need for a test that can assess clotting in a more 'global' manner, bey...

UNLABELLED Patients undergoing orthotopic liver transplantation are at high risk of bleeding complications. Several Authors have shown that thromboelastography (TEG)-based coagulation management and the administration of fibrinogen concentrate reduce the need for blood transfusion. METHODS We conducted a single-center, retrospective cohort observational study (Modena Polyclinic, Italy) on 386...

Thromboelastography (TEG) has been used in experimental animal studies since the early 1960s and in a routine clinical setting for the past decade. From the data currently available, it is clear that both the scope and limitations of TEG in animals resemble those observed in humans. TEG has been used to diagnose hypercoagulability in animals with disseminated intravascular coagulation, various ...