There are few studies in humans dealing with the relationship between physico-chemical properties of drugs and their systemic bioavailability after administration via oral inhalation route (Fpulm). Getting further insight determinants Fpulm pulmonary could be value for considered a delivery as result poor bioavailability, well local to anticipate undesirable effects. To better delineate paramet...

Abstract Glioblastoma (GB) is the most common and aggressive adult brain tumor with no cure. Brain stem cells (BTSCs) are a rare population of self-renewing multipotent in GB that contribute to tumorigenesis, therapeutic resistance, tumour recurrence. Here, we report CDK2 inhibitor suppresses BTSCs via OSM/OSMR/STAT3 signalling pathway. To begin with, performed high throughput screening (HTS) ~...

OBJECTIVE To evaluate the efficacy and safety of bipolar transurethral enucleation and resection of the prostate (B-TUERP) versus bipolar transurethral resection of the prostate (B-TURP) in the treatment of prostates larger than 60g. MATERIAL AND METHODS Clinical data for 270 BPH patients who underwent B-TUERP and 204 patients who underwent B-TURP for BPH from May 2007 to May 2013 at our cent...

UNLABELLED The aim was to substantiate the putative significance of angiotensin-converting enzyme (ACE) (insertion/deletion) I/D polymorphism on prostate cancer risk, BTPSA-A TPSA (before treatment-after treatment prostate-specific antigen) levels and tumor development. MATERIALS AND METHODS 48 prostate cancer patients and 51 healthy volunteers were included. The ACE I/D genotypes were determ...

Diabetes mellitus drugs currently available are sulfonylureas, biguanides, thiazolidines, and alpha glucoside inhibitors which widely used to control hyperglycemia. These cannot prevent complications of diabetes, these should not be continuously because it causes undesirable pathological conditions. The essential oil in lime peel is rich phenolics, especially flavonoids, can oxidative stress. T...

OBJECTIVE Although ultrasound-guided prostate needle biopsy is the gold standard method in the diagnosis of prostate cancer, biopsy schemes and the number of repeated biopsies are still controversial today. It is known that the rate of prostate cancer decreases with increasing prostate volume. In this study, we evaluated the effects of prostate volume on cancer detection in our patient series. ...

Recent studies reported that rs2252004 at 10q26 was significantly associated with prostate cancer (PCa) risk in a Japanese population and was subsequently confirmed in a Chinese population. We aimed to assess the relationship between this locus and risk/aggressiveness of benign prostatic hyperplasia (BPH). The current study included 426 BPH cases and 1,008 controls from Xinhua Hospital in Shang...

The phosphorus compounds of cotton embryos, particularly ribonucleic (RNA) and deoxyribonucleic (DNA) acid, and their metabolism during germination have not been intensively investigated with modern methods of analysis. In the period 1913 to 1918 Anderson (1) and Rather (9) elucidated the true nature of phytic acid, the principal form of seed phosphorus. Although Anderson obtained the hexaphosp...