AIMS AND BACKGROUND Upper urinary tract transitional cell carcinoma, a relatively rare tumor, is up to 100 times more frequent in regions with Balkan endemic nephropathy. Characteristics of transitional cell carcinoma in the endemic South Morava Region in Serbia in the previous 50 years were evaluated. PATIENTS We analyzed 477 cases with pathologically confirmed transitional cell carcinoma wh...

Protein complex of cyclin B1 and cyclin-dependent protein kinase 1 induces phosphorylation of key substrates that mediate cell cycle transition during the G(2)-M phase. It is believed that cyclin B1 accumulates in the S phase of the cell cycle and reaches the maximal level at mitosis but is absent in G(1)-phase cells. In the present study, we demonstrated that cyclin B1 was expressed in the arr...

The aim of this study was to evaluate the diagnostic value of AgNOR (Argyrophilic Nucleolar Organizer Proteins Region) staining in differentiation between malignant and non-malignant lesion, and histological grading of bladder transitional cell carcinoma. We have also showed the rate of AgNOR distribution score in the nuclear of malignant and non-neoplastic cells of bladder epithelium as an imp...

A number of studies have shown that people exploit transitional probabilities between successive syllables to segment a stream of artificial continuous speech into words. It is often assumed that what is actually exploited are the forward transitional probabilities (given XY, the probability that X will be followed by Y), even though the backward transitional probabilities (the probability that...

Transitional Safeguarding is emerging as a new concept in social work and care, inviting us to reconsider the binary divides of existing adult child safeguarding systems. These often fail adequately meet needs young people, particularly those experiencing extra-familial risks harm. acknowledges ‘in-between’ position people adolescence, relating both their physical psychosocial development but a...

Though remarkably robust, articular cartilage becomes susceptible to damage at high loading rates, particularly under shear. While several studies have measured the local static and steady-state shear properties of cartilage, it is the local viscoelastic properties that determine the tissue's ability to withstand physiological loading regimens. However, measuring local viscoelastic properties r...