Airway tracts serve as a conduit of transport in the respiratory system. Architecturally, these are composed of cartilage rings that offer flexibility and prevent collapse during normal breathing. To this end, the successful regeneration of an airway tract requires the presence of differentiated chondrocytes and airway smooth muscle cells. This study investigated the role of physiological dynam...

Titanium and its alloys are frequently used to replace structural components of the human body due their high mechanical strength, low stiffness, biocompatibility. In particular, use porous materials has improved implant stabilization promotion bone. However, it remains unclear which material properties geometrical cues optimal for a proper osteoinduction osseointegration. To that end, transpar...

Introduction: Although missing tooth is not life-threatening, it affects the quality of daily life. Stem cells have emerged as an important player in generation and maintenance many tissues. The role scaffolds has changed from a passive carrier to bioactive matrix, which can be used induce cellular behavior. aim this study was determine possibility regeneration dentin-pulp complex with dental p...

Blood vessel remodeling is crucial in tumor growth. Growth factors released by tumor cells and endothelium-extracellular matrix interactions are highlighted in tumor angiogenesis, however the physical tumor-endothelium interactions are highly neglected. Here, we report that the physical supports from hepatocellular carcinoma, HepG2 cells, are essential for the differentiation and remodeling of ...

Tubular sclerosis complex gene products TSC1 and TSC2 have evolutionarily conserved roles in cell growth from Drosophila to mammals. Here we reveal important roles for TSC1/2 in regulating intestinal stem cell (ISC) maintenance and differentiation of the enteroendocrine cell lineage in the Drosophila midgut. Loss of either the Tsc1 or Tsc2 gene in ISCs causes rapid ISC loss through TORC1 hypera...

Chemical gardens are tubular structures that consist of inorganic precipitate membranes formed under far-from-equilibrium conditions. Their possible existence in natural geological settings complicates the differentiation between Earth’s earliest microfossils and abiotic as well search for life signatures on other planets. Here, we address question whether laboratory-grown chemical can withstan...

The kidney possesses an impressive regeneration capacity and is the most performant among all tissues in the body. Yet ischaemic injury to the kidney produces acute tubular necrosis and apoptosis followed by tubular regeneration and recovery of renal function. Although mitotic cells are present in the tubules of postischaemic kidneys, the origins of the proliferating cells were considered until...