Different types of vaccines have been developed to elicit active immunization to treat various diseases, while suffer from limitation of efficacy. Herein, a novel immunostimulatory nanocomposite (CpG-Au@HBc VLP) was rationally designed by self-assembling engineered virus-like particles encapsulating CpG-gold nanoparticle conjugates through electrostatic interactions. The monodispersed and unifo...

Rapid, chip-scale, and cost-effective single particle detection of biological agents is of great importance to human health and national security. We report real-time, high-throughput detection and sizing of individual, low-index polystyrene nanoparticles and H1N1 virus. Our widefield, common path interferometer detects nanoparticles and viruses over a very large sensing area, orders of magnitu...

Plants are ideal for the production of protein-based nanomaterials because they synthesize and assemble complex multimeric proteins that cannot be expressed efficiently using other platforms. Plant viruses can be thought of as self-replicating proteinaceous nanomaterials generally stable and easily produced in high titers. We used Potato virus X (PVX), chimeric virus particles, and Cowpea mosai...

This review discusses briefly the preparation, electrochemistry, and electrogenerated chemiluminescence (ECL) as well as spectroscopic properties of organic nanoparticles. Organic nanoparticles, ranging from several tens of nanometers to hundreds of nanometers in diameter, were successfully prepared by various methods. Using a simple reprecipitation method, organic nanoparticles of a very small...

Porous hollow spherical and rod-like silica nanoparticles were obtained via a surfactant templating method adopting hydroxyapatite (HAp) nanoparticles as an etchable core material.

Homogeneous VO2 (B) nanorods approximately 100 nm in width and 1–2 mm in length have been fabricated via the hydrothermal process, and are then transformed into irregularly shaped V2O5 nanoparticles of several hundreds nanometers large and 20–30 nm thick after annealing the precursor material at 500 C for 30 min. Both the V2O5 sheet-like nanoparticles and VO2 (B) nanorods were tested as active ...

Unimolecular core−shell and hollow polymer nanoparticles with well-defined dimensions were crafted using spherical core−shell starlike diblock copolymers as templates. Monodisperse and structurally stable star-like diblock copolymers composed of inner degradable core blocks and outer photo-cross-linkable shell blocks were synthesized via a combination of two living polymerization techniques, na...

Silk-elastin-like protein polymers (SELPs) combine the mechanical and biological properties of silk and elastin. These properties have led to the development of various SELP-based materials for drug delivery. However, SELPs have rarely been developed into nanoparticles, partially due to the complicated fabrication procedures, nor assessed for potential as an anticancer drug delivery system. We ...

A simple and convenient approach denoted as gel-deposition-precipitation (G-D-P) for the preparation of core-shell-like silica@nickel species nanoparticles was studied systematically. Core-shell-like silica@nickel species nanoparticles consisted of a Si-rich core and a Ni-rich shell. The G-D-P process included two steps: one was the deposition-precipitation of nickel over the gelled colloidal s...