At one time, the diagnosis of a deficiency of vitamin B12 or folate was considered to be relatively straightforward. As knowledge has accumulated, the limitations of such tests as serum vitamin level measurements and the Schilling test have become apparent. With the development of newer tests, atypical and subclinical deficiency states have been recognized. In this review, available tests used ...

A t one time, the diagnosis of a deficiency of vitamin B12 or folate was considered to be relatively straightforward. As knowledge has accumulated, the limitations of such tests as serum vitamin level measurements and the Schilling test have become apparent. With the development of newer tests, atypical and subclinical deficiency states have been recognized. In this review, available tests used...

OBJECTIVE Vitamin B12 is involved in the production of adrenaline from noradrenaline. It is the cofactor involved in catecholamine degradation and plays a role in myelin synthesis. The current study aimed to investigate the association between vitamin B12 levels and postural orthostatic tachycardia syndrome (POTS) during adolescence when accelerated myelin synthesis increases the vitamin B12 ne...

Vitamin B12 deficiency in children often under reported and usually presents with nonspecific manifestations like neuropsychiatric symptoms, anaemia, glossitis chronic diarrhoea. Vegetarianism, minimal intake of animal products, poverty malnutrition may lead to vitamin deficiency. Laboratory reports show pancytopenia, megaloblasts bone marrow low serum cynocobalamine. Injectable is the treatmen...

Iron, vitamin B12, and folic acid deficiencies are among the most common deficiencies occurring after laparoscopic Roux-en-Y gastric bypass (LRYGB). The present study evaluates the effectiveness of a specially designed multivitamin supplement (WLS Forte, FitForMe, Rotterdam, the Netherlands) specifically developed for LRYGB patients.A triple-blind, randomized, 12-month study was conducted compa...

II ECOGNITION of the fully-developed megaloblast in deficiency of vitamm B12 or folic acid is not difficult. In the case of the “intermediate megaloblast” or “megaloblastoid” cell, however, identification of megaloblastic changes often becomes more difficult, and more subjective.1 The present study attempts to reduce this subjectivity by demonstrating a unique clockface chromatin pattern along ...

II ECOGNITION of the fully-developed megaloblast in deficiency of vitamm B12 or folic acid is not difficult. In the case of the “intermediate megaloblast” or “megaloblastoid” cell, however, identification of megaloblastic changes often becomes more difficult, and more subjective.1 The present study attempts to reduce this subjectivity by demonstrating a unique clockface chromatin pattern along ...

The studies of many investigators have led to a unified concept of the megaloblastic anemias as a single morphologic entity due to defective nucleoprotein synthesis from various causes. The vast majority of patients with megaloblastic anemia have been found to have deficiency of vitamin B12, of folic acid, or of both vitamins. For this reason, the possible interrelations of these two vitamins h...

BACKGROUND Vitamin B12 deficiency is associated with many adverse health outcomes and is highly prevalent worldwide. The present study assesses the prevalence and socio-demographic factors associated with vitamin B12 deficiency in a representative sample of pregnant women in Colombia. METHOD We used data from the cross-sectional, nationally representative survey (ENSIN, 2010). A total of 1.78...

Vitamin B12 deficiency is a well-known cause of megaloblastic anaemia and pancytopenia. However, the incidence in pregnancy is rarely reported. We present a case of a 32-year old multigravid woman who was diagnosed with megaloblastic anaemia since 22 weeks gestation and progressed to develop severe pancytopenia at 30 weeks gestation. She was also diagnosed with vitamin B12 deficiency related to...