Dinoflagellate bioluminescence provides a near-instantaneous reporter of cell response to flow. Although both fluid shear stress and acceleration are thought to be stimulatory, previous studies have used flow fields dominated by shear. In the present study, computational and experimental approaches were used to assess the relative contributions to bioluminescence stimulation of shear stress and...

Atherosclerotic plaque can cause severe stenosis in the artery lumen. Blood flow through a substantially narrowed artery may have different flow characteristics and produce different forces acting on the plaque surface and artery wall. The disturbed flow and force fields in the lumen may have serious implications on vascular endothelial cells, smooth muscle cells, and circulating blood cells. I...

We report an optical wall shear stress sensor based on the whispering gallery mode (WGM) shifts of dielectric micro-resonators. The optical resonators are spheres with a typical diameter of several hundred microns and they serve as the sensing element. The wall shear force acting on a movable plate is transmitted mechanically to the microsphere. As a result of the applied force, the shape of th...

The objective of this present numerical model is to investigate the effect of shape of stenosis on blood flow through an artery using power-law fluid model. Blood is modeled as power-law fluid in a uniform circular tube with an axially non-symmetric but radially symmetric stenosis. The expressions for dimensionless resistance to flow, wall shear stress and apparent viscosity have been obtained....

In this review, we summarized the effect of mechanical factors (shear and wall stress) on thin-cap fibroatheroma formation and rupture. To make this review understandable for a biology-oriented audience, we start with detailed definitions of relevant mechanical metrics. We then describe how biomechanics has supported histopathologic efforts to understand the basis of plaque rupture. In addition...

Flow-mediated dilation is aimed at normalization of local wall shear stress under varying blood flow conditions. Blood flow velocity and vessel diameter are continuous and opposing influences that modulate wall shear stress. We derived an index FMDv to quantify wall shear stress normalization performance by flow-mediated dilation in the brachial artery. In 22 fasting presumed healthy men, we fi...

In this paper a method is presented for torsional analysis of non-homogeneous tubes with arbitrarily shaped cross-sections. A previously presented method based on Bredt’s theory is extended to achieve formulas for torsional analysis. Shear modulus varies through the thickness according to a power law distribution. To validate the accuracy of the presented formulas for angle of twist and shear s...

In this study the pressure-drop, mean and rms axial velocity data are measured using a differential pressure transducer and a laser Doppler anemometer for the flow of Newtonian and non-Newtonian fluids in a concentric annular pipe (radius ratio =0.5) at various Reynolds numbers encompassing the laminar, transitional and turbulent regimes. Three different fluids are utilized; a semi-rigid shear-...

BACKGROUND Exercise has been found to either reduce or increase arterial stiffness. Land-based exercise modalities have been documented as effective physical therapies to decrease arterial stiffness. However, these land-based exercise modalities may not be suitable for overweight individuals, in terms of risks of joint injury. The purpose of this study was to determine the effects of 8-week swi...