نتایج جستجو برای: ایمونو هیستوشیمی ihc
تعداد نتایج: 6157 فیلتر نتایج به سال:
PURPOSE In 2009, the Evaluation of Genomic Applications in Practice and Prevention recommended that all colorectal cancers (CRCs) be screened for Lynch syndrome (LS) through microsatellite instability (MSI) or immunohistochemistry (IHC). No studies report how this process is implemented on a health system-wide basis. METHODS Since 2004, Cleveland Clinic has screened CRC specimens with MSI/IHC...
BACKGROUND Classification of breast cancer into intrinsic subtypes has clinical and epidemiologic importance. To examine accuracy of IHC-based methods for identifying intrinsic subtypes, a three-biomarker IHC panel was compared with the clinical record and RNA-based intrinsic (PAM50) subtypes. METHODS Automated scoring of estrogen receptor (ER), progesterone receptor (PR), and HER2 was perfor...
BACKGROUND HER2 assessment in biopsy specimens of gastric cancer (GC) is challenging because of the intratumoral heterogeneity. False negative results may be get because of limited biopsy material. The aim of this study is to explore how tumor-containing fragment number and biopsy specimen number affect HER2 immunohistochemistry (IHC) positive rate. METHODS Eight hundred and ninety biopsy spe...
PURPOSE Amplification of the human epidermal growth factor receptor 2 (HER2) gene occurs in 18% to 20% of breast cancers, and it is recognized as a prognostic and predictive marker. We investigated the HER2 status in Korean breast cancer by immunohistochemistry (IHC) and silver-enhanced in situ hybridization (SISH), as the first step toward building a nationwide quality assurance program for HE...
AFX: atypical fibroxanthoma HMWK: high molecular weight keratins IHC: immunohistochemical MMS: Mohs surgery SCC: squamous cell carcinoma INTRODUCTION Poorly differentiated spindle cell neoplasms pose a diagnostic challenge for dermatopathologists because of a lack of specific morphologic features on standard histopathology. Further characterization with immunohistochemical (IHC) studies is freq...
BACKGROUND Based on results of earlier studies, brain, heart and kidney are most commonly used for West Nile virus (WNV) detection in avian species. Both monoclonal and polyclonal antibodies have been used for the immunohistochemical diagnosis of WNV in these species. Thus far, no studies have been performed to compare the sensitivity and specificity of monoclonal and polyclonal antibodies in d...
INTRODUCTION The human epidermal growth factor receptor 2 (HER2) is an established biomarker for management of patients with breast cancer. While conventional testing of HER2 protein expression is based on semi-quantitative visual scoring of the immunohistochemistry (IHC) result, efforts to reduce inter-observer variation and to produce continuous estimates of the IHC data are potentiated by di...
دستگاه گوارش جوندگان سازگاریهای زیادی از نظر مورفولوژی، فیزیولوژی و هیستولوژی در رابطه با اکولوژی، نوع تغذیه و شرایط محیطی نشان می دهد، این تغییرات در جهت تطابق با نیازهای اکولوژیک و نوع تغذیه است . در این صورت با استفاده از رنگ آمیزیهای اختصاصی بافتهای دستگاه گوارش ، این اختلافات در ابعاد هیستوشیمی قابل بررسی خواهد بود. بنابراین با مقایسه مقاطع میکروسکوپی، اختلافها و تغییرات بافت شناسی و هیستو...
BACKGROUND The eligibility of breast cancer patients for human epidermal growth factor receptor 2 (HER2)-directed therapies is determined by the HER2 gene amplification and/or HER2 protein overexpression status of the breast tumor as determined by in situ hybridization (ISH) or immunohistochemistry (IHC), respectively. Our objective was to combine the US Food and Drug Administration (FDA)-appro...
افزایش درجه حرارت بیضه به دنبال نهان¬بیضه¬ای منجر به اختلال در اسپرماتوژنز و ناباروری می¬گردد. در تحقیق حاضر ضمن ارزیابی اثرات طولانی مدت حرارت در مدل نهان¬بیضه¬ای یک طرفه و دو طرفه بر پارامتر¬های اسپرم و ساختمان بیضه موش، بیان ژنهای دخیل در ایجاد مرگ سلولی برنامه ریزی شده در مدل نهان بیضه¬ای و راه¬های درمان کاهش سلول¬های ژرم در لوله¬¬های منی¬زا بعد از قرار گرفتن در معرض حرارت بررسی گردید. به م...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید