Еhe aim of the study was to investigate effectiveness a thick extract feverfew (Tanacetum parthenium L.) herb in chronic inflammation (adjuvant arthritis) rats.
 The anti-inflammatory properties water-alcohol (ETP) were studied model adjuvant arthritis (ADA) (0.1 ml Freund's (PAF), once subcutaneously at base tail white nonlinear male rats (body weight 200–220 g). After 7 days, introductio...

Parthenolide (PT) is responsible for the bioactivities of feverfew (Tanacetum parthenium). Apart from its potent anti-inflammatory effects, this compound has been reported to induce apoptosis in various cancer cells. However, little is known about its role in the process of tumor angiogenesis. In the present study, we investigated the effects and potential mechanisms of action of PT on angiogen...

Inflammation is a relevant factor in the pathogenesis of diabetes nephropathy (DN). Sesquiterpene lactones (SLs), originally isolated from Tanacetum parthenium, have been reported to exhibit anti-inflammatory effects but few studies have examined their effects on DN. To determine whether advanced oxidation protein products (AOPPs) can induce the expression of chemokine monocyte chemoattractant ...

BACKGROUND/AIMS Parthenolide (PT), a principle component derived from feverfew (Tanacetum parthenium), is a promising anticancer agent and has been shown to promote apoptotic cell death in various cancer cells. In this study, we focused on its functional role in apoptosis, migration, and invasion of human colorectal cancer (CRC) cells. METHODS SW620 cells were employed as representative human...

Herbal medicines have been used for centuries to treat different illnesses. Among more than 20,000 herbal medicines available for humans, a limited number have sufficiently been studied and numerous remained to be investigated for their efficacy in treating human diseases. A number of herbal products are in use for their immunosuppressive effects. This capacity of herbs may have useful applicat...

Non-small cell lung cancer (NSCLC), one type of lung cancer, owns high rates of morbidity and mortality. B-Raf is one of the promising oncogenic drivers of NSCLC. Parthenolide, a natural product, is mainly extracted from the herbal plant Tanacetum parthenium. The effect of parthenolide on NSCLC cells and its potential as B-Raf inhibitor were studied in this study. It's shown that parthenolide e...

The stereospecificity of the oxidation of trans-hex-2-en-l-01 and ethanol was determined for alcohol oxidases from Tanacetum vulgare leaves and from the yeast Candida boidinii. It was found that both enzymes remove the pro-1R hydrogen. The enzyme from Candida boidinii also removes the pro-1S hydrogen but t!o a much lesser degree.