Tumors from patients with high-grade aggressive prostate cancer (PCa) exhibit increased expression of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines. Despite the association between MAOA and aggressive PCa, it is unclear how MAOA promotes PCa progression. Here, we found that MAOA functions to induce epithelial-to-mesenchymal trans...

There are several cutting edge applications needing PCA methods for data on tori and we propose a novel torus-PCA method with important properties that can be generally applied. There are two existing general methods: tangent space PCA and geodesic PCA. However, unlike tangent space PCA, our torus-PCA honors the cyclic topology of the data space whereas, unlike geodesic PCA, our torus-PCA produ...

Principal component analysis (PCA) is an extensively used dimensionality reduction technique, with important applications in many fields such as pattern recognition, computer vision and statistics. It employs the eigenvectors of the covariance matrix of the data to project it on a lower dimensional subspace. Kernel PCA, a generalized version of PCA, performs PCA implicitly in a nonlinearly tran...

هدف: هدف پژوهش حاضر، تبیین الگوی برنامه درسی سواد رسانه‌ای در دوره ابتدایی نظام آموزش و پرورش است.مواد روش‌ها: رویکرد حاکم بر کیفی با استفاده از روش نظریه داده بنیاد انجام شده است. شرکت‌کنندگان این پژوهش، متخصصان صاحب‌نظران حوزه رسانه هستند که نمونه‌گیری هدفمند، 15 نفر آنان مصاحبه شد. ابزار گردآوری داده‌ها، نیمه‌ساختارمند بود تعداد محقق به اشباع نظری رسید.بحث نتیجه‌گیری: برای تجزیه تحلیل داده‌ه...

an ideal fusion method preserves the spectral information in fused image without spatial distortion. the pca is believed to be a well-known pan-sharpening approach and being widely used for its efficiency and high spatial resolution. however, it can distort the spectral characteristics of multispectral images. the current paper tries to present a new fusion method based on the same concept. in ...

Normal human monocytes and macrophages. as well as leukemic promyelocytes. generate potent procoagulant activity (PCA) resembling thromboplastin. In the present study only mild PCA was detected in a leukemic promyelocytic cell line (HL-60) and in promyelocytic cells induced to differentiate into neutrophils by dimethylsulfoxide (DMSO). After exposure to 1 2-O-tetradecanoylphorbol1 3-acetate (TP...

PLZF is a transcription repressor, which plays a critical role in development, spermatogenesis and oncogenesis. Down-regulation of PLZF has been found in various tumor cell lines. There has been virtually no tissue study on the expression of PLZF in prostate cancer (PCa). PCa is a heterogeneous disease, most of which are indolent and non-lethal. Currently there are no biomarkers that distinguis...

The first advance in the history of studies on prostate cancer (PCa) and androgens was the development of treatment with castration and administration of estrogen by Charles B. Huggins, who won the Nobel Prize in Physiology and Medicine. Since then, and for 70 years, androgen deprivation therapy has been the standard therapy for advanced PCa and the center of studies on PCa. However, recent adv...

The dysregulation of miR‑126 has been reported to correlate with the progression of several cancer types. The present study demonstrated that miR‑126 was significantly downregulated in prostate cancer (PCa) tissues compared with normal prostate tissues. In vitro and in vivo studies indicated that forced overexpression of miR‑126 significantly suppressed the proliferation of PCa cell lines. Addi...