Regulatory sequence detection is a fundamental challenge in computational biology. The transcription process in protein synthesis starts with the binding of the transcription factor (TF) to its binding site. These binding sites are short DNA segments that are called motifs. Different sites can bind to the same factor. This variability in binding sequences besides their low information content a...

A power management unit (PMU) is an essential block for diversified multi-functional low-power Internet of Things (IoT) and biomedical electronics. This paper includes a theoretical analysis high current, single-stage ac-dc, reconfigurable, dual output, regulating rectifier consisting pulse width modulation (PWM) frequency (PFM). The provides two independently regulated supply voltages 1.8 V 3....

The ability to reliably measure electromechanical properties is crucial the advancement of materials design for applications in fields ranging from biology and medicine energy storage electronics. With relentless miniaturization device technology, perform this characterization on nanoscale paramount. Due its probe micro- nano-scales, piezoresponse force microscopy (PFM) has become premier tool ...

In this research, we address the problem of evaluating physical stability (PS) to close tailings dams (TD) from medium-sized Chilean mining using artificial intelligence (AI) algorithms. The PS can be analyzed through study critical variables TD that allow estimating different potential failure mechanisms (PFM): seismic liquefaction, slope instability, static overtopping, and piping, which may ...

BACKGROUND The reduction of the pelvic floor muscles (PFM) strength is a major cause of stress urinary incontinence (SUI). OBJECTIVES To compare active and passive forces, and vaginal cavity aperture in continent and stress urinary incontinent women. METHOD The study included a total of thirty-two women, sixteen continent women (group 1--G1) and sixteen women with SUI (group 2--G2). To eval...

OBJECTIVES €‚ Neuromuscular electrical stimulation (NMES) is commonly used to treat lower urinary tract dysfunctions. This study evaluated the efficacy of a novel externally applied stimulator in the treatment of stress urinary incontinence (SUI). MATERIALS AND METHODS €‚ Nine women were included in this study. Provocative tests included a cough and jumping jack test assessed via pad weight. ...

Pelvic floor muscle training (PFMT) is the most commonly recommended conservative therapy for women with SUI. PFMT is used to rehabilitate or strengthen the PFMs; it increases the ability to produce an increase in urethral resistance, provided the patient is able to perform a correct voluntary PFM contraction. It counteracts PFM weakness, increasing support for the urethra and bladder, and impr...

OBJECTIVE To develop a classification scale for manometry of pelvic floor muscles (PFM) in Brazilian women, according to the modified Oxford scale. METHODS A cross sectional study, with 288 women enrolled in the Maternity, Natal, Brazil. Manometry and PFM strength data were collected and classified according to the modified Oxford scale. A simple linear regression was performed to determine t...