Introduction: Neuropathic pain syndromes are changes resulting from damage to neuronal pathways that are characterized by spontaneous burning sensation with accompanying allodynia and hyperalgesia. Since the treatments of neuropathic pain are poorly understood and existing treatments are often ineffective, it is important to increase our understanding of the neuropathic pain states in order ...

The aim of the study was to assess the influence of thalidomide on megakaryocytes (MK) in patients with multiple myeloma (MM). The study was based on bone marrow trephine biopsies from 12 patients with MM before initiation of thalidomide administration and after three months of its duration. The morphometric examinations were done, using image analysis (DP 12). Quantitative assessment of MK and...

Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. In order to evaluate MK-801 effects on monkeys' PPI, we tested eight capuchin monkeys (Sapajus spp...

Six experiments studied the role of conditioned stimulus (CS) familiarity in determining the effects of the N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 on fear extinction. Systemic administration of MK-801 (0.1 mg/kg) impaired initial extinction but not reextinction learning. MK-801 impaired reextinction learning when the CS was relatively novel during reextinction training but not i...

One of the major issues associated with industrial production of menaquinone-7 (MK-7) is the low fermentation yield. In this study, we investigated the effect of iron oxide nanoparticles coated with 3-aminopropyltriethoxysilane (IONs@APTES) on the production of MK-7 using B. subtilis (ATCC 6633). Decoration of B. subtilis cells with IONs@APTES significantly enhanced both MK-7 production and yie...

MK-927 is a novel topical carbonic anhydrase inhibitor (CAI). We present the first single-dose clinical trial of MK-927 in 24 patients with bilateral primary open-angle glaucoma or ocular hypertension. This investigation was conducted as a two-centre, double-masked, randomised, placebo controlled study. Patients received one drop of 2% MK-927 in one eye and placebo in the other eye. Modified di...

Internal friction and speed of sound were measured on a-SiO2 above 6 mK using a torsional oscillator at 90 kHz, controlling for thermal decoupling, vibrational heating, background losses, and nonlinear effects. Strain amplitudes epsilon(A) = 10(-8) mark the transition between the linear and nonlinear regimes. In the former, agreement with the tunneling model was observed for both internal frict...

Intermolecular interactions in cyclometalated Ru complex dye (FT89) dimers, carbazole organic dye (MK-45 and MK-111) dimers, FT89-MK-45 complexes, and FT89-MK-111 complexes were investigated using density functional theory (DFT) and time-dependent DFT (TD-DFT) to elucidate the improvement mechanism of dye-sensitized solar cell (DSSC) performance due to cosensitization with FT89 and MK dyes. All...