نتایج جستجو برای: نانوالیاف plga
تعداد نتایج: 4089 فیلتر نتایج به سال:
Poly-lactide-co-glycolide (PLGA) is one of the few polymers approved by the US Food and Drug Administration as a carrier for drug administration in humans; therefore, it is one of the most used materials in the formulation of polymeric nanoparticles (NPs) for therapeutic purposes. Because the cellular uptake of polymeric NPs is a hot topic in the nanomedicine field, the development of technique...
Abstract Sepsis, a life-threatening organ dysfunction induced by severe infection and uncontrolled host immune response, threatens the health of people all over world. Herein, type nanoparticle formulation with simple components is synthesized encapsulating monophosphoryl lipid A (MPLA), TLR4 agonist, poly(lactic-co-glycolic acid) (PLGA) nanoparticle. The obtained nanoparticles (MPLA@PLGA) coul...
The aim of this study is to explore an improved double emulsion technology with in situ reaction of lysine (Lys) and glutaraldehyde (GA) for fabricating autofluorescent Lys-poly(lactic-co-glycolic acid)-GA (Lys-PLGA-GA) microcapsules as novel ultrasonic/fluorescent dual-modality contrast agents. Scanning electron microscope (SEM) and static light scattering (SLS) results show that 80% of the Ly...
The aim of the present study was the direct covalent coupling of the epidermal growth factor receptor (EGFR)-specific monoclonal antibody (mAb) to the surface of poly(lactide)-co-glycolide (PLGA)-polyethylene glycol (PEG) nanoparticles in order to achieve a cell type-specific drug carrier system against pancreatic cancer. The PLGA-PEG-NH2 diblock copolymer was synthesized by coupling reaction v...
Cancer is one of the leading causes of death in most parts of the world and is a very serious cause of concern particularly in developing countries. In this work, we prepared and evaluated the aptamer-labeled paclitaxel-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Apt-PTX-PLGA NPs) which can ameliorate drug bioavailability and enable accurate drug targeting to cancer cells with co...
نانوالیاف(engelhard corporation titanosilicate number 10/polyacrylonitrile) ets-10/pan به عنوان یک مبادله کننده کامپوزیتی برای جذب فلزات سنگین سنتز وبهینه شد. چندین پارامتر در تهیه این جاذب، بررسی و در نهایت سایز نانوالیاف حدودا به75 نانومتر رسید. ساختار بوسیله میکروسکوپ الکترونی روبشیsem)) وطیف سنجی پراش انرژی پرتو ایکس((edax شناسایی و اندازه گیری منافذ و نسبت سطح به حجم جاذب با استفاده از آ...
Background and Objective: Adenoid cystic carcinoma (ACC) and polymorphous low grade adenocarcinoma (PLGA) originate from ductal and myoepithelial salivary gland cells. They have a similar histologic appearance, but with different clinical behavior, treatment and prognosis. CD117 is a tyrosine kinase that is expressed by melanocytes, mastocytes and germinal cells. Our knowledge about its express...
Introduction : Nowadays, using drug delivery is an essential method to improve cancer therapy through decreasing drug toxicity and increasing efficiency of treatment. Silibinin (C25H22O10), a polyphenolic flavonoid which is isolated from the milk thistle plant, has various applications in cancer therapy but it has hydrophobic structure with low water solubility and bioavailability. To increase ...
Poly(lactic-co-glycolic acid) ([PLGA] 50:50 wt% PLA:PGA) films with a flat surface and with 27 nm, 190 nm, 300 nm, 400 nm, and 520 nm nanopatterns were fabricated using a cast-mold process. The nanopatterns were transferred from self-assembled polystyrene (PS) beads to PLGA films through polydimethylsiloxane (PDMS) molds. The surface features, root-mean- square (RMS) roughness, and wettability ...
Gene delivery holds therapeutic promise for the treatment of neurological diseases and spinal cord injury. Although several studies have investigated the use of non-viral vectors, such as polyethylenimine (PEI), their clinical value is limited by their cytotoxicity. Recently, biodegradable poly (lactide-co-glycolide) (PLGA) nanospheres have been explored as non-viral vectors. Here, we show that...
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