Synthetic triterpenoids are antioxidant inflammation modulators (AIMs) that exhibit broad anticancer activity. AIMs bind to KEAP1 and inhibit its ability to promote NRF2 degradation. As a result, NRF2 increases transcription of genes that restore redox balance and reduce inflammation. AIMs inhibit tumor growth and metastasis by increasing NRF2 activity in the tumor microenvironment and by modul...

The purpose of this study was to compare the variation in hemoglobin (Hgb) values among various point-of-care (POC) analyzers available on the market. Eight analyzers (Gem 3000, ABL 720, ABL 77, Rapidpoint 405, IL 682, GemOPL, Hb 201+, and manual/centrifugation) were compared with the Hgb values from the Beckman Coulter LH750. A total of 72 patient samples were analyzed on each test instrument....

This research presents the numerical and empirical efforts to investigate effect of friction stir welding (FSW) parameters on weld temperature, strength, hardness for novel brass known as yellow 405-20. The approaches used measure temperature strength were studied first time 405-20 their validations via studies. Two models simulated including transient thermal analysis static structural analysi...

BACKGROUND Antimicrobial resistance is driven by multiple factors. Resolving the threat to human and animal health presented by drug-resistant infections remains a societal challenge that demands close collaboration between scientists and citizens. We compared current public views about key contributing factors to antimicrobial resistance with those expressed by experts. METHODS Overarching f...

Background and aims—Laser induced fluorescence (LIF) from colonic mucosa was measured in vivo with and without ä aminolevulinic acid (ALA) in an attempt to diVerentiate between neoplasia and non-neoplasia in real time during colonoscopy. Methods—Spectra from 32 adenomas, 68 normal sites, and 14 hyperplastic polyps in 41 patients were obtained with a point monitoring system. Twenty one of the pa...