نتایج جستجو برای: ژن hoxb13
تعداد نتایج: 15960 فیلتر نتایج به سال:
Blood-based biomarkers are critical in metastatic prostate cancer, where characteristic bone metastases are not readily sampled, and they may enable risk stratification in localized disease. We established a sensitive and high-throughput strategy for analyzing prostate circulating tumor cells (CTC) using microfluidic cell enrichment followed by digital quantitation of prostate-derived transcrip...
BACKGROUND Genome-wide association studies have identified polymorphisms associated with breast cancer subtypes and across multiple population subgroups; however, few studies to date have applied linkage analysis to other population groups. METHODS We performed the first genome-wide breast cancer linkage analysis in 106 African American families (comprising 179 affected and 79 unaffected memb...
کلزا یکی از گیاهان مهم روغنی می باشد که تنها بعد از سویا و نخل روغنی جایگاه سوم را در تولید جهانی به خود اختصاص داده است. این گیاه عضو خانواده براسیکا می باشد. یکی از مهمترین عوامل محدود کننده تولید دانه های روغنی از جمله کلزا مجموعه ای از آفات هستند که به این گیاه خسارت وارد می کنند. آفات حشره ای گیاهان روغنی کلزا، منحصراً مختص خانواده شب بو هستند که از جمله این آفات، آفات پروانه ای می باشند. آ...
Background and Objective: Tamoxifen is the most commonly used treatment for the patients with breast cancer called ER +, which prevents the expression of genes that are effective in the growth and proliferation of cancer cells by estrogen. Resistant to Tamoxifen is a major clinical problem in breast cancer treatment. In recent studies, the role of microRNAs in tamoxifen resistance has been rais...
This paper studies the performance of preconditioned stochastic gradient descent (PSGD), which can be regarded as an enhance stochastic Newton method with the ability to handle gradient noise and non-convexity at the same time. We have improved the implementation of PSGD, unrevealed its relationship to equilibrated stochastic gradient descent (ESGD) and feature normalization, and provided a sof...
HOX genes encode transcription factors that function to establish basic body pattern during embryogenesis and maintain the function of specific organs in the adult. Recent studies have demonstrated that HOX genes are also involved in oncogenesis in a range of malignancies. To elucidate whether HOX genes contribute to ovarian carcinogenesis, we created an expression profile of HOX genes using ov...
An efficient approach to characterizing the disease burden of rare genetic variants is to impute them into large well-phenotyped cohorts with existing genome-wide genotype data using large sequenced referenced panels. The success of this approach hinges on the accuracy of rare variant imputation, which remains controversial. For example, a recent study suggested that one cannot adequately imput...
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