Background: Excitotoxicity is a common pathological process in neurodegenerative diseases associated with overactivity of N-methyl-D-aspartate (NMDA) and P/Q type voltage-gated calcium (Cav2.1) channels. Omega-lycotoxin-Gsp2671g is a therapeutic tool to modulate overactive Cav2.1 (P/Q type) channels. Omega-lycotoxin binds to Cav2.1 channels with high affinity and selectivity. This study aimed t...

Seafood consumption enhances intake of omega-3 long-chain (≥C₂₀) polyunsaturated fatty acids (termed LC omega-3 oils). Humans biosynthesize only small amounts of LC-omega-3, so they are considered semi-essential nutrients in our diet. Concern has been raised that farmed fish now contain lower LC omega-3 content than wild-harvested seafood due to the use of oil blending in diets fed to farmed fi...

the purpose of this study was to investigate the effect of polyvinyl chloride vacuum packaging(170 micron thickness) on omega 3 and omega 6 contents of carp fillet at -18 ° c during 180 day storage. the tests were done with the use of gas chromatography. total content of w6 in fresh fish was 18.21%. after 180 day storage the amount of w6 in control sample changed to 14.85% but for vacuumed fill...

Several sources of information suggest that human beings evolved on a diet with a ratio of omega-6 to omega-3 essential fatty acids (EFA) of approximately 1 whereas in Western diets the ratio is 15/1-16.7/1. Western diets are deficient in omega-3 fatty acids, and have excessive amounts of omega-6 fatty acids compared with the diet on which human beings evolved and their genetic patterns were es...

There is evidence that alteration in plasma fatty acid composition may play a role in certain neurological disorders. This case control study was conducted to evaluate the association between plasma fatty acid levels and mental retardation in Korean children. Plasma phospholipid fatty acids, plasma lipids, dietary fatty acids and selected nutrients were measured in 31 mentally retarded boys (me...

prostate cancer is the most common cancer in america and canada, and is the sixth most common cancer worldwide. dietary factors play an important role in prostate cancer development; one of them is dietary fat, particularly pufa intake. thus, this study aimed to review the current articles on the correlation between pufa and prostate cancer. we searched the pubmed database, and selected article...

BACKGROUND This research was conducted to explore the relationships between the levels of omega-3 fatty acids in serum phospholipid and key fatty acid ratios including potential cut-offs for risk factor assessment with respect to coronary heart disease and fatal ischemic heart disease. METHODS Blood samples (n = 2053) were obtained from free-living subjects in North America and processed for ...