Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Although anti-RSV Ab prophylaxis has greatly reduced infant mortality in the United States, there is currently no vaccine or effective antiviral therapy. RSV fusion (F) protein activates cells through TLR4. Two single nucleotide polymorphisms (SNPs) encoding Asp299Gly and Thr399Ile substitutions in the TLR4 ecto...

For the present study, blood samples from 35 Murrah dam-progeny pairs and semen samples of their sires were collected. All six primers successfully amplified the genomic DNA from all the animals. The mean observed heterozygosity (Ho) within the population was found to be 0.5438 and it ranged from 0.375 (CSSM43) to 0.775 (CSSM61). Average expected Levene’s and Nei’s heterozygosity (Hep) were 0.6...

Abstract The Vanilla genus is a complex taxonomic group characterized by vegetative reproduction mode combined with intra- and inter-specific hybridizations, polyploidy events. These factors strongly impact the diversification of complicate delimitation taxa. Among hundred species, planifolia Jacks. ex Andrews × tahitensis J. W. Moore are main cultivated aromatic species. We applied Genotyping-...

mahi sefid (cyprinidae) is an economically important fish in the south caspian sea. specimens was collected from the lamir river, sefid rud, shir rud and tajan rivers and analyzed at 38 microsatellite dna loci. eight primers out of the thirty analyzed loci were polymorphic in all sampling regions. the highest observed heterozygosity (1) was in locus ca1 in sefid rud and lowest was 0.07 in locus...

Growth and egg production data from F2 layer chickens produced from a mating of MHC-heterozygous B15B44 sires to B15B44 and B15B43 dams were analyzed for associations with the level of the individual's genomic heterozygosity and dam MHC. The F1 sires and dams were produced from mating of birds from two genetically distinct, highly inbred lines. Genomic heterozygosity (expressed as composite ban...

Litchi is an important fruit tree in tropical and subtropical areas of the world. However, there is widespread confusion regarding litchi cultivar nomenclature and detailed information of genetic relationships among litchi germplasm is unclear. In the present study, the potential of single nucleotide polymorphism (SNP) for the identification of 96 representative litchi accessions and their gene...

Valproic acid (VPA) is one of the most commonly prescribed drugs for the treatment of epilepsy. Interindividual variability in VPA dose and plasma concentration may reflect functional consequences of genetic polymorphisms in genes encoding drug-metabolizing enzymes. The aim of this study was to determine the relationship between plasma concentrations of VPA and single nucleotide polymorphisms (...

The pituitary-specific transcription factor (PIT-1) gene is a candidate gene for growth, carcass and also for milk yield traits. In dairy farm animals, the main goal of the selection is the improvement of milk yield and composition. The genes of milk proteins and hormones are excellent candidate genes for linkage analysis with quantitative trait loci (QTL) because of their biological significan...