نتایج جستجو برای: ad 40
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Tensor-based morphometry can recover three-dimensional longitudinal brain changes over time by nonlinearly registering baseline to follow-up MRI scans of the same subject. Here, we compared the anatomical distribution of longitudinal brain structural changes, over 12 months, using a subset of the ADNI dataset consisting of 20 patients with Alzheimer's disease (AD), 40 healthy elderly controls, ...
the prevalence of atopic dermatitis (ad) and obesity have been increasing considerably in korean school-children. ad is a chronic pruritic recurrent inflammatory skin disorder. leptin is secreted by adipocytes which has been suggested to be immunologically active; however, their role in ad has not yet been well understood. a total of 227 subjects out of 2,109 elementary school children were def...
Background: Type 2 diabetes mellitus (T2DM) is one of the significant risk factors for Alzheimer disease (AD). Defects in insulin signaling pathway induce AD hallmarks mainly through activation of glycogen synthase kinase-3β (GSK-3β) pathway. Objectives: In this study, we investigated the expression of GSK-3β and insulin receptor (IR) genes in the hippocampi of an animal model of sporadic AD ...
BACKGROUND Individuals with Down's syndrome (DS) develop early Alzheimer's disease (AD) with β-amyloid (Aβ) plaque pathology. The extra amyloid precursor protein (APP) gene copy in DS is believed to result in a 50% increase in Aβ production, but it is unclear how this relates to the development of other AD hallmarks, including axonal degeneration and microglia cell activation, and to other neur...
Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, share several features. These include having similar β-sheet secondary structures, binding to the same receptor, and being degraded by the same protease. Thus, amylin may be...
Excessive extracellular deposition of amyloid beta (Abeta) peptide in neuritic plaques and degeneration of forebrain cholinergic neurones, which innervate the hippocampus and the neocortex, are the invariant characteristic features of Alzheimer's disease (AD). Studies of the pathological changes that characterize AD, together with several other lines of evidence, indicate that Abeta accumulatio...
Previous trials have shown promising effects of intranasally administered insulin for adults with Alzheimer's disease dementia (AD) or amnestic mild cognitive impairment (MCI). These trials used regular insulin, which has a shorter half-life compared to long-lasting insulin analogues such as insulin detemir. The current trial examined whether intranasal insulin detemir improves cognition or dai...
هدف تحقیق حاضر، ارزیابی نقص توجه انتخابی در افراد مسن مبتلا به بیماری آلزایمـر و سالم با استفاده از روش تکلیف دوگانه بود. شرکت کنندگان شامل 23 فرد (11 زن و 12 مرد) با دامنه سنی 62 تا 81 سال که 13 نفر از آنها مبتلا به بیماری آلزایمر(ad) و10 نفر افراد مسن سالم(ec) که دارای عملکرد شناختی طبیعی بودند، در این مطالعه شرکت داشتند. شناسایی افراد مبتلا به آلزایمر و سالم بر اساس تشخیص پزشک و پرسشنامه وضع...
Ar-Benzyladriamycin-14-valerate (AD 198) ¡s a highly lipophilic ana logue of Adriamycin with novel cytotoxic mechanisms, greater in vivo antitumor activity, and the ability to circumvent multidrug resistance due to P-glycoprotein-mediated drug efflux or decreased topoisomerase II activity. To identify the mechanism(s) which may confer AD 198 resist ance, J774.2 mouse macrophage-like cells were...
چکیده: به منظور بررسی کشت مخلوط ارزن معمولی(panicummiliaceum)و گاوزبان(boragoofficinalis)تحت تأثیرتراکم های مختلف کاشت آزمایشی در قالب طرح بلوک های کامل تصادفی با سه تکرار در سال زراعی 90-1389در مزرعه تحقیقاتیدانشکده کشاورزی دانشگاه زابل اجرا گردید. هر کرت آزمایشی شامل 8 ردیف کاشت با طول 5 متر و فاصله بین ردیف ها 30 سانتیمتر بود تیمارها شامل ارزن با تراکم ثابت و فاصله بین دو بوته 4 سانتیمتر (a...
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