pulmonary adenocarcinoma is one of the major types of lung cancers in which metastasis is not uncommon. hereby, we report a case of pulmonary adenocarcinoma with multiple muscular, cutaneous, pancreatic and peritoneal metastases. actually, all these features occurring in one patient makes it an extraordinary case. a rare anatomic variation, double inferior vena cava (ivcs), was another rare man...

[This corrects the article DOI: 10.1371/journal.pone.0171824.].

Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of the ligands in canonical Wnt/β-catenin signaling pathway, which contributes to the carcinogenesis and progression of lung cancer cell lines. The aim of this study was to evaluate the association between Wnt3a and EMT-related proteins (E-cadherin and...

The Hippo pathway and its downstream transcriptional co-activator Yap influence lung cancer, but the nature of the Yap contribution has been unclear. Using a genetically engineered mouse lung cancer model, we show that Yap deletion completely blocks KrasG12D and p53 loss-driven adenocarcinoma initiation and progression, whereas heterozygosity for Yap partially suppresses lung cancer growth and ...

BACKGROUND Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with few treatment options. Reliable tumour cell lines for mesothelioma research are rare. Claudins seem to be attractive targets for cancer therapy. AIM To establish a claudin-based MPM phenotype and to verify whether it is preserved in vitro and in vivo. MATERIALS AND METHODS Claudin-3 and -4 expression was examined...

In China, the incidence rate and mortality of gastric cancer are in second place among all tumors pathological type is mainly adenocarcinoma. The higher prevalence requires us to do more research. It great significance study antitumor effect hydroxysafflor yellow pigment A aim this was investigate inhibitory on human adenocarcinoma BGC-823 xenograft nude mice. animal model established mice carr...

The Fifth edition of the World Health Organization classification digestive system and American Joint Committee on Cancer staging manual contain substantial refinements information for esophageal tumors. epithelial tumors esophagus are classified as benign, dysplasia, malignant groups. Dysplasia is divided into Barrett dysplasia squamous graded either low-grade or high-grade. Malignant often ad...

Adenocarcinoma is the predominant histological subtype of lung cancer, the leading cause of cancer deaths in the world. At stage I, the tumor is cured by surgery alone in about 60% of cases. Markers are needed to stratify patients by prognostic outcomes and may help in devising more effective therapies for poor prognosis patients. To achieve this goal, we used an integrated strategy combining m...