This study aimed to evaluate the antileishmanial efficacy of oxaliplatin against Leishmania major both in-vitro and in-vivo. The IC50, CC50, and SI of oxaliplatin against promastigotes, murine macrophages, Raw 264.7 cells, and intramacrophage amastigotes of L. major were investigated in-vitro. The effects of this drug on intrace...

Brush-type macromolecules (BMs) have attracted much attention over the past decades because of their unique properties and potential applications in nanoscience, drug-delivery systems, photonics. A two-step strategy synthesis polycarbonate-grafted copolymers with either star-shaped or brush-typed morphologies using a “grafting from” approach is reported; backbone these all-polycarbonate graft m...

background: transfusion is the mainstay treatment of patients with thalassemia major and occasionally in thalassemia intermediate. alloimmunization is an unwanted side effect of blood transfusion. the present study intended to determine the frequency of alloimmunization in patients with β- thalassemia major and thalassemia intermediate in southwest iran. patients and methods: this was a cross-s...

the variation in climatic variables like temperature, humidity and radiations were recognized as the potential hazards in the growth and production of all domestic livestock species. thermal environment is a major factor that can negatively affect both production and reproduction in dairy animals, especially in animals of high genetic merit. among the stressors, heat stress has been of major co...

Tuberculosis is a major health problem in Portugal. To begin characterizing the population structure of Mycobacterium tuberculosis, spoligotyping was used for the systematic typing, through consecutive sampling, of patient isolates from the Amadora-Sintra area of Greater Lisbon. Distribution amongst major spoligotype families, including the Latin American Mediterranean (LAM), T, Haarlem and Bei...

This study firstly analyzes the impact of energy intensities and income on CO2 emissions in Russia, applying different estimation methods to data period from 1990 2020. In addition, forecasts considering 2030 targets under assumptions assesses achievability set target. The results concluded that GDP fossil fuel have a statistically positive emissions. Also, we found forecasted value for 2030, b...