Plant proteins can be classified into families and superfamilies based on their sequence relationships. Comparison of these families with accepted lists of plant food-protein allergens demonstrates that only a small number of families contain characterized allergens with most of those that sensitize via the gastrointestinal tract falling into only two large superfamilies. These observations are...

In this work a statistical evaluation of alignment based features for prediction of protein allergenicity was performed. The evaluation consisted of four key components: 1) A new high quality in-house database consisting of 318 allergenic and 1007 non-allergenic amino acid sequences. 2) Three different supervised classification algorithms. 3) A large set of local alignments procedures using a w...

This review will address cross-reactivity of pollen, fungal, and animal aeroallergens. In the 15 years or so that have transpired since similar reviews on pollen cross-reactivity were published, significant additional information both on cross-allergenicity and on plant systematics has become available (1,2). This review will attempt to incorporate those advances. Cross-reactivity among foods w...

Based on the scientific uncertainty surrounding both the molecular characterization of genetically engineered (GE) crops as well as the detection of potential allergenicity, there is more than enough uncertainty to decide to require labeling of foods produced via GE as a risk management measure as a way to identify unintended health effects that may occur post approval. If foods are not labeled...

Background B cell epitopes corresponding to interaction zones between proteins and immune system are a mean to explore intrinsic features of proteins linked to allergenicity. The project PREDEXPITOPE was funded by the French National Research Agency to develop a bioinformatics strategy for prediction of B cell epitopes of allergens. The objective was to distinguish epitopic from non epitopic ar...

Chitosan is a natural polycationic linear polysaccharide derived from chitin. The low solubility of chitosan in neutral and alkaline solution limits its application. Nevertheless, chemical modification into composites or hydrogels brings to it new functional properties for different applications. Chitosans are recognized as versatile biomaterials because of their non-toxicity, low allergenicity...

7. Hancock BW, Naysmith A. Hypersensitivity to chlorocresolpreserved heparin. BMJ. 1975;27:746--7. 8. Freitas JP, Brandão FM. Contact urticaria to chlorocresol. Contact Dermatitis. 1986;15:252. 9. Yamano T, Shimizu M, Noda T. Allergenicity evaluation of p-chloro-m-cresol and p-chloro-m-xylenol by non-radioactive murine local lymph-node assay and multipledose guinea pig maximization test. Toxico...

Abstract Background The lack of effective treatment against the highly infectious SARS-CoV-2 has aggravated already catastrophic global health issue. Here, in an attempt to design efficient vaccine, a thorough immunoinformatics approach was followed predict most suitable viral proteins epitopes for building that vaccine . Methods amino acid sequences four structural (S, M, N, E) along with one ...