Introduction Dermal fillers are used for multiple cosmetic indications including gluteal and thigh augmentation. Complications, although infrequent, are increasing due to the dramatic growth of dermal filler use. Our aim was to describe how the complication of infected silicone granulomas can present following lower limb augmentation. Methods Two cases presented with pain, oedema, and erythem...

Most regimens for intravitreal injection of antibiotics are based on studies in normal albino rabbits. We examined the effect of two variables, infection and pigmentation, on the ocular distribution of an intravitreal injection of 50 micrograms of gentamicin in rabbit eyes. The half-life of gentamicin in the vitreous of normal pigmented rabbits after intravitreal administration was 24 hr. Antib...

Composite data describing ocular pharmacokinetics are unreliable because of intersubject variation. To address this problem, an animal model was developed in which multiple aqueous samples from single subjects were obtained. Following direct anterior chamber or intravenous administration of amikacin or chloramphenicol, pharmacokinetic analysis of drug concentrations in the serum and anterior ch...

The aim of this study was to evaluate the clinical results of patients with vesicoureteral reflux, which were treated with subureteral injection of small-size (80-120 μm) dextranomer/hyaluronic acid copolymer (Dx/HA). Data of 75 children (105 renal units) who underwent STING procedure with small-size Dx/HA for the treatment of vesicoureteral reflux (VUR) in our clinic between 2008 and 2012 were...

Endoscopic botulinum toxin injection is considered a safe and viable option for the management of achalasia [1,2]. Although esophageal perforation and mediastinitis are well-documented complications of this treatment, pseudo-aneurysm formation of the thoracic aorta following intersphincteric injection is exceedingly rare [3]. We report the first published fatality from a thoracic aorta pseudo-a...

Background Mitomycin C (MMC) as an alkylating agent is miscellaneous an antineoplastic, antibiotic and ophthalmic agent. Here we aim to report a case of inadvertent intravitreal MMC injection instead of Avastin in case of diabetic macular edema. Case presentation A 53 years old woman was planned to receive intravitreal Avastin injection, but accidentally, 0.05 ml of MMC 0.2% was injected. Bes...

IT is just twenty-nine years since the discovery of penicillin and sixteen years since it w,as first used as a therapeutic substance. Penicillin, the first antibiotic, was the forerunner of some thousands of antibiotic substances, only a small fraction of which have provred to be of therapeutic value. One of the main reasons for this was the toxicity of many of the substances and their tendency...