The therapeutic effect of combined drugs on cervical cancer has been confirmed. Whether antiprogrammed cell death protein 1 antibody with paclitaxel mediates the phosphoinositide 3-kinase-protein kinase B pathway to regulate still needs further research. 20 nude mice received subcutaneous administration Henrietta Lacks cells establish model which was then assigned into blank control group, grou...

The clear cell renal carcinoma (ccRCC) is the most frequent and aggresive subtype of usually detected at an already advanced stage. It might even be observed as a metabolic disease since complex molecular changes disturbed redox homeostasis are its hallmark. As certain characteristic for tumorigenesis, while some other metastatic disease, identification modifications could also point out stage ...

The chemical speciation of iron (Fe) in oceans is influenced by ambient pH, dissolved oxygen, and the concentrations strengths binding sites organic matter (DOM). Here, we derived new nonideal competitive adsorption (NICA) constants for Fe(III) to marine DOM via pH-Fe titrations. We used calculate derive apparent solubility (SFe(III)app) water column across Peruvian shelf slope region. define S...

Lipotoxicity caused by saturated fatty acids (SFAs) induces tissue damage and inflammation in metabolic disorders. SCD1 (stearoyl-coenzyme A desaturase 1) converts SFAs to mono-unsaturated fatty acids (MUFAs) that are incorporated into triglycerides and stored in lipid droplets. SCD1 thus helps protect hepatocytes from lipotoxicity and its reduced expression is associated with increased lipotox...

305: 1183–1190 40. Murota S, Morita I, Suda N. The control of vascular endothelial cell injury. Ann N Y Acad Sci 1990; 598: 182–187 41. Lee S, Moon SO, Kim W et al. Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury. Nephrol Dial Transplant 2006; 21: 2085–2095 42. Camps M, Nichols A, Arkinstall S. Dual specificity phosphatases: a gene family for control o...

Objective: Cuscuta campestris or common dodder is a holoparasitic  plant  that  has  been valorized for treatment of liver injury and cancer prevention in traditional medicine. Recently, extract of C. campestris had shown moderate antimicrobial properties and cytotoxic effects. In this study, we examined the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by hydr...

The purpose of this study was to determine the role Oxidized Low Density Lipoprotein (OX LDL) promotes insufficient autophagy and apoptosis ovarian granulosa cells through regulation Reactive Oxygen Species (ROS) mediated PI3K Akt/mTOR pathway.

BACKGROUND Astroglial cells are frequently involved in malignant transformation. Besides apoptosis, necroptosis, a different form of regulated cell death, seems to be related with glioblastoma genesis, proliferation, angiogenesis and invasion. In the present work we elucidated mechanisms of necroptosis in cultured astrocytes, and compared them with apoptosis, caused by staurosporine. MATERIAL...

Oxidized low density lipoprotein (OxLDL) has multiple proatherogenic effects, including induction of apoptosis. We have recently shown that OxLDL markedly downregulates insulin-like growth factor-1 receptor (IGF-1R) in human aortic smooth muscle cells, and that IGF-1R overexpression blocks OxLDL-induced apoptosis. We hypothesized that specific OxLDL-triggered signaling events led to IGF-1R down...