After unilateral ovariectomy of 4-day-cyclic rats, plasma FSH increased over control values for 6--12 h after the surgery regardless of whether unilateral ovariectomy was performed before or after 08:00 h on the day of dioestrus, after which time compensatory ovulation did not occur at the next oestrus. Pituitary content of FSH also increased from 6 h after unilateral ovariectomy. In contrast, ...

Free radicals increase in the presence of diabetes. Lycopene is a powerful antioxidant. The goal of the present study was to determine the effect of diabetes on rat ovaries and the protective role of lycopene in that context. Experimental diabetes was induced with 50 mg÷kg streptozotocin. Rats were randomly separated into four groups, as follows: control + corn oil, control + lycopene, diabetes...

Follicular selection predominantly depends on granulosa cell apoptosis in porcine ovaries, but the molecular mechanisms regulating the induction of apoptosis in granulosa cells during follicular selection remain incompletely understood. To determine the role of X-linked inhibitor of apoptosis protein (XIAP), which suppresses caspase-3, -7 and -9 activities and acts as an endogenous inhibitor of...

Quinalphos is a toxic organophosphate pesticide having a wide applicability to control pests in a number of vegetable crops like ladyfinger, brinjal, cauliflower etc. due to its good penetrative properties and long residual action in animals. The present investigation was carried out to determine its toxic effects on reproduction in the female albino rats. Technical quinalphos (2 mg/kg body wei...

Background: In the past 2 decades, the survival rates for many of the malignancies that affectyoung women have significantly improved. For many of these malignancies, survival rates exceed 80-90%. Therefore, the remote effects of cancer treatment have recently gained worldwide interest, andthe protection against iatrogenic infertility caused by chemotherapy assumes high priority. Busulfan is a ...

Fas ligand (FasL) and its receptor Fas have been implicated in granulosa cell apoptosis during follicular atresia. Although interferon-gamma (IFN-γ) is believed to be involved in the regulation Fas expression in differentiated granulosa or granulosa-luteal cells, the expression of this cytokine and its role in the regulation of the granulosa cell Fas/FasL system and apoptosis during follicular ...

BACKGROUND Hyperandrogenism is the primary manifestation of polycystic ovary syndrome (PCOS), which appears to be caused by excess exposure to androgen. As such, androgenized animal models have been developed and investigated to study the etiology of PCOS. Anti-Mullerian hormone (AMH) is known to be associated with follicle growth, and its levels are two to three times higher in women with PCOS...

Background: Many health problems are related to lifestyle and dietary factors. Since ancient times, food additives such as sulfites have been used to preserve foods. Diverse effects of sulfites on multiple organs have been reported but its effect on female reproductive organ has not been fully elucidated. The aim of this study was to investigate the effects of sodium metabisulfite (SMB) on ovar...

The guinea pig is an excellent animal model for studying reproductive biology of adult humans and most domestic animals. Yet, whether this animal might serve as a good model for embryonic stage investigations and determinations of signals affecting or directing ovary development remains unknown. These questions were addressed by examining morphological evolution and the expression of biomarkers...