INTRODUCTION: Activated platelets are known to release many kinds of growth factors such as Platelet Derived Growth Factor (PDGF) and Transforming Growth Factor-β (TGF-β). Platelet-rich plasma (PRP) is a fraction of plasma in which platelets are concentrated and is reported to be utilized as a source of multiple growth factors that promote tissue repair. Recent studies has shown that platelet r...

BACKGROUND AND OBJECTIVE The therapeutic benefits of platelet-rich plasma (PRP) for the promotion of healing and regeneration of periodontal tissues are thought to result from enrichment in growth factors released from platelets. The aim of this study was to evaluate the effects of specific growth factors released from PRP on endothelial cell proliferation. MATERIAL AND METHODS The levels of ...

  Background: Osteoarthritis is a disabling musculoskeletal disease with no definite treatment. This study compared the effect of Platelet-rich plasma (PRP) and Transcutaneous Electrical Nerve Stimulation (TENS) plus exercise in the treatment of patients with knee joint osteoarthritis.   Methods : 54 eligible patients with knee osteoarthritis were randomly allocated into two groups. (IRCT201211...

Introduction. Platelet-Rich Plasma (PRP) is rich in growth factors, playing important role in tissue healing. The wide variation of reported protocols for preparation of PRP leads to variable compositions, which induce different biological responses and prevent results comparison. This study aims to highlight relevant aspects of the centrifugation step to obtain reproducible results and overall...

Da belastbare Daten zur Wirksamkeit von autologem plättchenreichem Plasma (engl. Platelet Rich Plasma/PRP) bei degenerativen Kniegelenkerkrankungen bislang fehlen, sprechen sich viele klinische Leitlinien gegen eine entsprechende Injektionsbehandlung aus. Dennoch kommt die Therapie in der Praxis zunehmend zum Einsatz. Eine randomisierte Doppelblindstudie (RESTORE) prüfte nun, ob Personen mit me...

BACKGROUND The use of platelet-rich plasma (PRP) is an innovative clinical therapy, especially in arthroscopic rotator cuff repair. The purpose of this study was to compare the clinical improvement and tendon-to-bone healing with and without PRP therapy in arthroscopic rotator cuff repair. METHODS A systematic search was done in the major medical databases to evaluate the studies using PRP th...

OBJECTIVE The purposes of this study were to (1) evaluate correlations among platelet, leukocyte, growth factor, and cytokine concentrations in canine platelet-rich plasmas (PRPs) produced from five different canine PRP-concentrating systems and (2) compare the effects of different activation protocols on platelet activation and growth factor release from one of these PRPs. METHODS PRP was ma...

With an aging population worldwide, the frequency of osteoporotic fractures is increasing. Therefore, biological methods to enhance the internal fixation of osteoporotic fractures becomes more important to reduce the societal burden of care. The purposes of this study were to evaluate the role of platelet-rich plasma (PRP) in the treatment of osteoporotic fractures and to clarify the best conce...