A considerable number of randomized controlled trials have shown that Internet-based interventions are effective in the treatment of depression. In the past years a large number of studies are currently focusing onhow this knowledge can beused and implemented in mental health care, including preventive services, primary care, specialized mental health care, and general medical care. Furthermore...

In this issue, Molecular Cancer Therapeutics inaugurates a new feature-The Cutting Edge: Spotlight on Clinical Response-whose objective is the rapid publication of breaking discoveries regarding target- or mechanism-based clinical responses in cancer. Targeted molecules are poised to alter the landscape of clinical cancer treatment. For example, because they can distinguish cancer cells from th...

Snakebite is listed as a neglected tropical disease by the WHO. Up to 2.5 million people are bitten each year, resulting in up to 125.000 deaths, and 400.000 permanent disabilities due to tissue necrosis. We investigated 94 plant species from Africa, which are used in traditional medicine to treat snakebites, for inhibitory activity against the necrosis enzymes hyaluronidases, phospholipase A2 ...

Standardization is a method used to compare observed and expected rates of a given disease/outcome by removing the influence of factors that may confound the comparison. There are two major standardization methods: one is used when the 'standard' is the structure of a population (direct method) and the other when the 'standard' is a set of specific event rates (indirect method). The direct stan...

social phobia is one of the anxiety disorders. the people wit h social phobia fear social situations and they are afraid to meet and talk with others and try avoid social situations .social phobia influence on academic and occupational function. many researches have confirmed the effect of family therapy based on cognigive-behavioral approach on social phobia. the main purpose of the present re...

The construction of the American Psychiatric Association's diagnostic manual has been guided primarily by concerns of construct validity rather than of clinical utility, despite claims by its authors that the highest priority has in fact been clinical utility. The purpose of this article was to further articulate the concept and importance of utility when constructing and evaluating a diagnosti...

Implant surgery complications are frequent occurrences in dental practice and knowledge in the management of these cases is essential. The aim of this review was to highlight the challenges of treatment plan-related, anatomy-related, and procedure-related surgical complications as well as to discuss the etiology, management and treatment options to achieve a satisfactory treatment outcome.