OBJECTIVE Newer non-benzodiazepines zolpidem and zopiclone ("Z-drugs") are often prescribed instead of benzodiazepine hypnotics, although there is no evidence of differences in effectiveness and safety. Aim was to compare perceptions on benefits and harms of benzodiazepines and Z-drugs between general practitioners (GPs) and community pharmacists (CPs). METHODS A questionnaire was mailed to a...

Cytochrome P450 3A4 is the predominant isoform in liver, and it metabolizes more than 50% of the clinical drugs commonly used. However, CYP3A4 is also responsible for metabolic activation of drugs, leading to liver injury. Benzodiazepines are widely used as hypnotics and sedatives for anxiety, but some of them induce liver injury in humans. To clarify whether benzodiazepines are metabolically a...

Natural and unnatural disasters, beside taking lives, can expose survivors to the risk of developing multiple negative outcomes. Among them, occurrence mental health problems stands out, which require non-pharmacological pharmacological management, with use psychotropic drugs such as antidepressants or benzodiazepines. In this context, review aimed bring together studies that address drugs, and...

BACKGROUND The purpose of this study was to determine, in the context of a hospital addiction unit, which benzodiazepines were abused and to look for correlations with the characteristics of detoxified patients. METHODS A retrospective study was carried out using the database of hospital admissions to the addiction unit for detoxification from 2003 to 2010. RESULTS Of 879 admissions to the ...

The combined use of opioid and benzodiazepine medications increases the risk of hazardous effects, such as respiratory depression. Although recent increases in outpatient use of opioid prescriptions have been documented, there are limited data regarding rates and correlates of combined opioid and benzodiazepines among adults in outpatient settings. Our objective was to examine annual trends in ...

BACKGROUND Although a decrease in new prescribing has occurred for anxiolytic benzodiazepines, concerns have been raised that a 'core' of long-term users has been left behind. Typically, elderly people represent this 'core', using the benzodiazepines as hypnotics. OBJECTIVE The present study focuses on the reasons why hypnotic benzodiazepines are used for protracted lengths of time. By examin...

BACKGROUND Acute intake of benzodiazepines is followed by concentration-dependent deterioration of performance in controlled experimental studies. Whether this is true in a population of benzodiazepine users is uncertain. We studied the relationship in a population of suspected drugged drivers. METHODS In Norway physicians examine and take blood samples from nearly all suspected drivers. Our ...

Buprenorphine is abused in several countries notwithstanding its benefits as an analgesic and opioid agonist treatment medication. Benzodiazepines alcohol have previously been associated with buprenorphine toxicity. This study elucidates the role of emerging concomitant drugs different groups user deaths. All cases Finnish national post-mortem toxicology database from 2016–2019 which or norbupr...

The main objective of this research was to evaluate the prescribing ratio benzodiazepines in patients suffering from a disease other than mental disorder. A prospective cross-sectional study conducted at 24 different community pharmacies and medical stores District Sukkur. Participants with age more 18 years using Benzodiazepines were included study. Average Participants, who participated, 38 ±...