BACKGROUND Late onset disorders are often associated with cerebral disfunctioning and cognitive impairment in elderly patients. It is unknown whether the age of onset affects cognition in patients with bipolar disorder. The authors compare cognition and clinical characteristics of early- and late-onset bipolar patients in a stable and euthymic condition. METHOD One hundred and nineteen older ...

UNLABELLED Alcoholism is present in approximately 40-60% of bipolar patients. This comorbidity between bipolar disorder and alcoholism is high and may result from existence of common genetic factors for the two disorders. In both disorders, dysregulation of the dopaminergic neurotransmission had been implicated. Association analyses revealed several candidate genes acting in the dopaminergic pa...

BACKGROUND While pain is frequently associated with unipolar depression, few studies have investigated the link between pain and bipolar depression. In the present study we estimated the prevalence and characteristics of pain among patients with bipolar depression treated by psychiatrists in their regular clinical practice. The study was designed to identify factors associated with the manifest...

OBJECTIVE Persistent neurocognitive deficits have been described in bipolar mood disorder. As far as we are aware, no study have examined whether the cognitive impairment is presented in the same way in a Brazilian sample. METHOD Cognitive function of 66 patients with bipolar disorder (32 with depressive symptoms and 34 euthymic) and 28 healthy subjects was examined using a complete cognitive...

The effect of reassessing patients with depression and resistant depression in a CMHT caseload using the DSM IV criteria for bipolar I and bipolar II conditions inevitably leads to the diagnosis of more patients with bipolar disorder. This has an effect on the number of patients within the population of the CMHT who fall within the psychotic clusters of HONOS-PBR. This should effect the resourc...

Physicians treating patients with bipolar depression have a unique challenge when considering drug therapy. Historically, patients with bipolar depression have been treated with SSRIs or other medications commonly utilized with patients presenting with non-bipolar depression. Indeed, many of these medications are not ideal for patients suffering from bipolar depression. Recently, a class of sec...

BACKGROUND This study aims to establish if adult patients with major depressive disorder (MDD) and childhood Attention Deficit/Hyperactivity disorder (ADHD) symptoms would be more frequently within the bipolar spectrum than depressed patients without childhood ADHD. METHODS This study was carried out in outpatients recruited by psychiatrists in private practice, with 3963 participants being i...

Aim: Bipolar disorder is a multifactorial being linked with dysregulation of several genes. Among the recently acknowledged factors in pathophysiology bipolar are non-coding RNAs (ncRNAs). Methods: We searched PubMed and Google Scholar databases to find studies that assessed expression profile miRNAs, lncRNAs circRNAs disorder. Results: Dysregulated ncRNAs patients have been enriched neuron-rel...

Schizophrenia patients and a subset of patients with bipolar disorder suffer from psychosis. Both disorder have been found to have shared genetic risk factors. In order to assess these claims further, endophenotypes for these disorders need to be established. Electroencephalography provides a means for measuring low level auditory processing through event related potentials. In the study a dich...

In this research study, we present a novel frame work for handling bipolar fuzzy soft information by combining bipolar fuzzy soft sets with graphs. We introduce several basic notions concerning bipolar fuzzy soft graphs and investigate some related properties. We also consider the application of the bipolar fuzzy soft graphs. In particular, three efficient algorithms are developed to solve mult...