Inflammation and degradation of bone are two closely linked processes. Chronic inflammatory arthritis not only leads to inflammatory bone loss but it also involves local erosion of articular bone. This osteo-destructive feature of chronic inflammatory arthritis is a major cause of disability in patients with rheumatoid arthritis. Osteoclasts are essential for the resorption of mineralized carti...

Among the several rotenoids, amorphigenin is isolated from the leaves of Amopha Fruticosa and it is known that has anti-proliferative effects and anti-cnacer effects in many cell types. The main aim of this study was to investigate the effects of amorphigenin on osteoclast differentiation in vitro and on LPS treated inflammatory bone loss model in vivo. We show here that amorphigenin inhibited ...

Introduction: Patients with chronic inflammatory diseases have increased bone loss and bone fragility and are at increased risk of fracture. Although anti-resorptive drugs are effective in blocking inflammation-induced bone loss, they are less effective at rebuilding bone. We have previously shown that treatment with sclerostin antibody (Scl-AbI) builds bone and can prevent or restore bone loss...

Introduction: Osteoarthritis (OA) is a disease of a whole joint. Yet most of the diagnostic methods are focused mainly on cartilage degeneration and erosion. However, there is increasing evidence that the subchondral bone significantly contributes to the pathogenesis of OA. It has even been suggested that first tissue-level changes in OA occur in the subchondral bone before any signs of degener...

directed against RANKL, has been demonstrated to increase bone mass at both axial and peripheral skeletal sites, as well as in trabecular and cortical areas of bone [8]. It can probably prevent not only the generalized bone loss in RA, but also the joint destruction inhibiting the bone erosion [9]. On the other hand, zoledronic acid is a potent third-generation aminobisphosphonate that is thoug...

INTRODUCTION Patients with chronic inflammatory diseases have increased bone loss and bone fragility and are at increased risk of fracture. Although anti-resorptive drugs are effective in blocking inflammation-induced bone loss, they are less effective at rebuilding bone. We have previously shown that treatment with sclerostin antibody (Scl-AbI) builds bone and can prevent or restore bone loss ...

C17 was first described about ten years ago as a gene expressed in CD34+ cells. A more recent study has suggested a role for C17 in chondrogenesis and development of cartilage. However, based on sequence analysis, we believe that C17 has homology to IL-2 and hence we present the hypothesis that C17 is a cytokine possessing immune-regulatory properties. We provide evidence that C17 is a secreted...

OBJECTIVE To explore the association between chronic suppurative otitis media and sensorineural hearing loss. METHOD The files of 147 patients with unilateral chronic suppurative media were reviewed in a retrospective study. Differences between diseased and control ear bone conduction thresholds were analysed by the paired student's t-test over the four frequencies (0.5 kHz, 1.0 kHz, 2.0 kHz,...