background : biomarkers accepted for clinical use in breast cancer have low sensitivity and specificity. thus, there is a need for new markers to assist in the diagnosis, prognosis and follow-up of breast cancer patients. this study aims to investigate the diagnostic, prognostic and follow-up role of serum bcl-2, bax and p53 proteins in breast cancer patients in comparison with those of serum c...

Aromatase inhibitors (AIs) have a proven role in the treatment of early and metastatic breast cancer. The success of tamoxifen in reducing the relative risk of developing hormone-sensitive breast cancer in chemoprevention trials has been hampered by their long-term toxicity profile. AIs have the potential to further reduce rates of breast cancer in high-risk postmenopausal women. This article r...

Cancer-associated retinopathy (CAR) is an uncommon paraneoplastic disorder of the retina that is frequently associated with breast cancer in pre- and postmenopausal women older than 50 years. In this review, we will give an update on the current knowledge regarding the association of antiretinal autoantibodies with the breast-CAR syndrome. Women with breast cancer and visual indications of CAR ...

breast cancer is the most important and prevalent cancer in women that can be managed if detected in the early stages. recently, there has been much focus on the use of epigenetic changes such as dna methylation in early detection of cancer. as recent research has put forth dok7 cpg island methylation as an epimarker, in the present study, using a quantification method, a cohort of iranian spor...

background: transvaginal ultrasound is one of the most common means to examine endometrial cavity lesions although its negative results are more valuable. saline sonohysterography can reduce the number of false negative rates of endometrial lesions diagnoses in tamoxifen consumers. the objective of this study was to determine the diagnostic values of saline infusion sonohysterography (sis) and ...

background: in the modern lifestyle, the increase in cancer and related chronic disorders is a major public health problem. in spite of different methods used for the treatment of these conditions, natural medicines have high demands due to their significant effects as immune enhancement and therapeutic agents and fewer side effects in comparison with other treatment methods. hence, this study ...

objective(s): breast cancer is the most common type of cancer among women worldwide. this study investigated the expression and clinical significance of activating transcription factor 3 (atf3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   materials and methods : atf3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent norm...

Breast cancer is the most common cancer and considered as the second cause of mortality in woman (Begum et al., 2012). Early detection of this pathology is very useful way to decrease it (Tjemslanda and Soreide, 2004). Currently, mammography stills the gold standard test for breast cancer screening (Tarhan et al., 2014). However, breast cancer may be hard to detect in some women with dense brea...